Hyperhomocysteinemia potentiates megakaryocyte differentiation and thrombopoiesis via GH-PI3K-Akt ax...
Hyperhomocysteinemia potentiates megakaryocyte differentiation and thrombopoiesis via GH-PI3K-Akt axis
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Author / Creator
Lei, Wenjing , Liu, Zhuoliang , Su, Zhiyuan , Meng, Panpan , Zhou, Chun , Chen, Xiaomei , Hu, Zheng , Xiao, An , Zhou, Miaomiao , Huang, Liping , Zhang, Yiyue , Qin, Xianhui , Wang, Junping , Zhu, Fengxin and Nie, Jing
Publisher
England: BioMed Central Ltd
Journal title
Language
English
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Publication information
Publisher
England: BioMed Central Ltd
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Scope and Contents
Contents
Hyperhomocysteinemia (HHcy) is closely associated with thrombotic diseases such as myocardial infarction and stroke. Enhanced platelet activation was observed in animals and humans with HHcy. However, the influence of HHcy on thrombopoiesis remains largely unknown. Here, we reported increased platelet count (PLT) in mice and zebrafish with HHcy. In...
Alternative Titles
Full title
Hyperhomocysteinemia potentiates megakaryocyte differentiation and thrombopoiesis via GH-PI3K-Akt axis
Authors, Artists and Contributors
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_f47f902f076044f78bdcb8941b7edf9c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f47f902f076044f78bdcb8941b7edf9c
Other Identifiers
ISSN
1756-8722
E-ISSN
1756-8722
DOI
10.1186/s13045-023-01481-x
