Spontaneous generation of infectious prion disease in transgenic mice
Spontaneous generation of infectious prion disease in transgenic mice
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United States: U.S. National Center for Infectious Diseases
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Language
English
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Publisher
United States: U.S. National Center for Infectious Diseases
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We generated transgenic mice expressing bovine cellular prion protein (PrP(C)) with a leucine substitution at codon 113 (113L). This protein is homologous to human protein with mutation 102L, and its genetic link with Gerstmann-Sträussler-Scheinker syndrome has been established. This mutation in bovine PrP(C) causes a fully penetrant, lethal, spong...
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Full title
Spontaneous generation of infectious prion disease in transgenic mice
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TN_cdi_doaj_primary_oai_doaj_org_article_f4eec1200adf4068814944b3da7f0e6b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f4eec1200adf4068814944b3da7f0e6b
Other Identifiers
ISSN
1080-6040
E-ISSN
1080-6059
DOI
10.3201/eid1912.130106
