EpCAM ectodomain EpEX is a ligand of EGFR that counteracts EGF-mediated epithelial-mesenchymal trans...
EpCAM ectodomain EpEX is a ligand of EGFR that counteracts EGF-mediated epithelial-mesenchymal transition through modulation of phospho-ERK1/2 in head and neck cancers
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Author / Creator
Pan, Min , Schinke, Henrik , Luxenburger, Elke , Kranz, Gisela , Shakhtour, Julius , Libl, Darko , Huang, Yuanchi , Gaber, Aljaž , Pavšič, Miha , Lenarčič, Brigita , Kitz, Julia , Jakob, Mark , Schwenk-Zieger, Sabina , Canis, Martin , Hess, Julia , Unger, Kristian , Baumeister, Philipp and Gires, Olivier
Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Head and neck squamous cell carcinomas (HNSCCs) are characterized by outstanding molecular heterogeneity that results in severe therapy resistance and poor clinical outcome. Inter- and intratumoral heterogeneity in epithelial-mesenchymal transition (EMT) was recently revealed as a major parameter of poor clinical outcome. Here, we addressed the exp...
Alternative Titles
Full title
EpCAM ectodomain EpEX is a ligand of EGFR that counteracts EGF-mediated epithelial-mesenchymal transition through modulation of phospho-ERK1/2 in head and neck cancers
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TN_cdi_doaj_primary_oai_doaj_org_article_f50b19f0c6f44b07ae3d77277cf46991
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f50b19f0c6f44b07ae3d77277cf46991
Other Identifiers
ISSN
1545-7885,1544-9173
E-ISSN
1545-7885
DOI
10.1371/journal.pbio.2006624
