ATAXIN-2 intermediate-length polyglutamine expansions elicit ALS-associated metabolic and immune phe...
ATAXIN-2 intermediate-length polyglutamine expansions elicit ALS-associated metabolic and immune phenotypes
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Author / Creator
Vieira de Sá, Renata , Sudria-Lopez, Emma , Cañizares Luna, Marta , Harschnitz, Oliver , van den Heuvel, Dianne M. A. , Kling, Sandra , Vonk, Danielle , Westeneng, Henk-Jan , Karst, Henk , Bloemenkamp, Lauri , Varderidou-Minasian, Suzy , Schlegel, Domino K. , Mars, Mayte , Broekhoven, Mark H. , van Kronenburg, Nicky C. H. , Adolfs, Youri , Vangoor, Vamshidhar R. , de Jongh, Rianne , Ljubikj, Tijana , Peeters, Lianne , Seeler, Sabine , Mocholi, Enric , Basak, Onur , Gordon, David , Giuliani, Fabrizio , Verhoeff, Tessa , Korsten, Giel , Calafat Pla, Teresa , Venø, Morten T. , Kjems, Jørgen , Talbot, Kevin , van Es, Michael A. , Veldink, Jan H. , van den Berg, Leonard H. , Zelina, Pavol and Pasterkamp, R. Jeroen
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Intermediate-length repeat expansions in ATAXIN-2 (ATXN2) are the strongest genetic risk factor for amyotrophic lateral sclerosis (ALS). At the molecular level, ATXN2 intermediate expansions enhance TDP-43 toxicity and pathology. However, whether this triggers ALS pathogenesis at the cellular and functional level remains unknown. Here, we combine p...
Alternative Titles
Full title
ATAXIN-2 intermediate-length polyglutamine expansions elicit ALS-associated metabolic and immune phenotypes
Authors, Artists and Contributors
Author / Creator
Sudria-Lopez, Emma
Cañizares Luna, Marta
Harschnitz, Oliver
van den Heuvel, Dianne M. A.
Kling, Sandra
Vonk, Danielle
Westeneng, Henk-Jan
Karst, Henk
Bloemenkamp, Lauri
Varderidou-Minasian, Suzy
Schlegel, Domino K.
Mars, Mayte
Broekhoven, Mark H.
van Kronenburg, Nicky C. H.
Adolfs, Youri
Vangoor, Vamshidhar R.
de Jongh, Rianne
Ljubikj, Tijana
Peeters, Lianne
Seeler, Sabine
Mocholi, Enric
Basak, Onur
Gordon, David
Giuliani, Fabrizio
Verhoeff, Tessa
Korsten, Giel
Calafat Pla, Teresa
Venø, Morten T.
Kjems, Jørgen
Talbot, Kevin
van Es, Michael A.
Veldink, Jan H.
van den Berg, Leonard H.
Zelina, Pavol
Pasterkamp, R. Jeroen
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_f542924285bc411ab2ef82b8bba3d188
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f542924285bc411ab2ef82b8bba3d188
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-51676-0
