Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells
Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells
About this item
Full title
Author / Creator
Rattigan, Kevin M. , Brabcova, Zuzana , Sarnello, Daniele , Zarou, Martha M. , Roy, Kiron , Kwan, Ryan , de Beauchamp, Lucie , Dawson, Amy , Ianniciello, Angela , Khalaf, Ahmed , Kalkman, Eric R. , Scott, Mary T. , Dunn, Karen , Sumpton, David , Michie, Alison M. , Copland, Mhairi , Tardito, Saverio , Gottlieb, Eyal and Vignir Helgason, G.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Deregulated oxidative metabolism is a hallmark of leukaemia. While tyrosine kinase inhibitors (TKIs) such as imatinib have increased survival of chronic myeloid leukaemia (CML) patients, they fail to eradicate disease-initiating leukemic stem cells (LSCs). Whether TKI-treated CML LSCs remain metabolically deregulated is unknown. Using clinically an...
Alternative Titles
Full title
Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells
Authors, Artists and Contributors
Author / Creator
Brabcova, Zuzana
Sarnello, Daniele
Zarou, Martha M.
Roy, Kiron
Kwan, Ryan
de Beauchamp, Lucie
Dawson, Amy
Ianniciello, Angela
Khalaf, Ahmed
Kalkman, Eric R.
Scott, Mary T.
Dunn, Karen
Sumpton, David
Michie, Alison M.
Copland, Mhairi
Tardito, Saverio
Gottlieb, Eyal
Vignir Helgason, G.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_f6923fc9708841a5bf7e890a6863e86a
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f6923fc9708841a5bf7e890a6863e86a
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-40222-z
