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Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells
Author / Creator:Kuntz, Elodie M ; Baquero, Pablo ; Michie, Alison M ; Dunn, Karen ; Tardito, Saverio ; Holyoake, Tessa L ; Helgason, G Vignir ; Gottlieb, Eyal
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2017-10, Vol.23 (10), p.1234-1240
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Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells
Author / Creator:Rattigan, Kevin M. ; Brabcova, Zuzana ; Sarnello, Daniele ; Zarou, Martha M. ; Roy, Kiron ; Kwan, Ryan ; de Beauchamp, Lucie ; Dawson, Amy ; Ianniciello, Angela ; Khalaf, Ahmed ; Kalkman, Eric R. ; Scott, Mary T. ; Dunn, Karen ; Sumpton, David ; Michie, Alison M. ; Copland, Mhairi ; Tardito, Saverio ; Gottlieb, Eyal ; Vignir Helgason, G.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2023-08, Vol.14 (1), p.4634-4634, Article 4634
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Activating p53 abolishes self-renewal of quiescent leukaemic stem cells in residual CML disease
Author / Creator:Scott, Mary T. ; Liu, Wei ; Mitchell, Rebecca ; Clarke, Cassie J. ; Kinstrie, Ross ; Warren, Felix ; Almasoudi, Hassan ; Stevens, Thomas ; Dunn, Karen ; Pritchard, John ; Drotar, Mark E. ; Michie, Alison M. ; Jørgensen, Heather G. ; Higgins, Brian ; Copland, Mhairi ; Vetrie, David
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2024-01, Vol.15 (1), p.651-651, Article 651
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The MYC–NFATC2 axis maintains the cell cycle and mitochondrial function in acute myeloid leukaemia cells
Author / Creator:Patterson, Shaun D. ; Massett, Matthew E. ; Huang, Xu ; Jørgensen, Heather G. ; Michie, Alison M.
Publisher:United States: John Wiley & Sons, Inc
Journal title:Molecular oncology, 2024-09, Vol.18 (9), p.2234-2254
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Bioengineered niches that recreate physiological extracellular matrix organisation to support long-term haematopoietic stem cells
Author / Creator:Donnelly, Hannah ; Ross, Ewan ; Xiao, Yinbo ; Hermantara, Rio ; Taqi, Aqeel F. ; Doherty-Boyd, W. Sebastian ; Cassels, Jennifer ; Tsimbouri, Penelope. M. ; Dunn, Karen M. ; Hay, Jodie ; Cheng, Annie ; Meek, R. M. Dominic ; Jain, Nikhil ; West, Christopher ; Wheadon, Helen ; Michie, Alison M. ; Peault, Bruno ; West, Adam G. ; Salmeron-Sanchez, Manuel ; Dalby, Matthew J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2024-07, Vol.15 (1), p.5791-18, Article 5791
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A KDM4A-PAF1-mediated epigenomic network is essential for acute myeloid leukemia cell self-renewal and survival
Author / Creator:Massett, Matthew E. ; Monaghan, Laura ; Patterson, Shaun ; Mannion, Niamh ; Bunschoten, Roderick P. ; Hoose, Alex ; Marmiroli, Sandra ; Liskamp, Robert M. J. ; Jørgensen, Heather G. ; Vetrie, David ; Michie, Alison M. ; Huang, Xu
Publisher:London: Nature Publishing Group UK
Journal title:Cell death & disease, 2021-06, Vol.12 (6), p.573-573, Article 573
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mTORC1 activity is essential for erythropoiesis and B cell lineage commitment
Author / Creator:Malik, Natasha ; Dunn, Karen M. ; Cassels, Jennifer ; Hay, Jodie ; Estell, Christopher ; Sansom, Owen J. ; Michie, Alison M.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2019-11, Vol.9 (1), p.16917-12, Article 16917
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Nfix Expression Critically Modulates Early B Lymphopoiesis and Myelopoiesis
Author / Creator:O’Connor, Caitríona ; Campos, Joana ; Osinski, Jason M. ; Gronostajski, Richard M. ; Michie, Alison M. ; Keeshan, Karen
Publisher:United States: Public Library of Science
Journal title:PloS one, 2015-03, Vol.10 (3), p.e0120102-e0120102
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Dasatinib Inhibits CXCR4 Signaling in Chronic Lymphocytic Leukaemia Cells and Impairs Migration Towards CXCL12
Author / Creator:McCaig, Alison M. ; Cosimo, Emilio ; Leach, Michael T. ; Michie, Alison M.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2012-11, Vol.7 (11), p.e48929-e48929
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The chemical chaperone 4-phenylbutyric acid rescues molecular cell defects of COL3A1 mutations that cause vascular Ehlers Danlos Syndrome
Author / Creator:Omar, Ramla ; Lee, Michelle AW ; Gonzalez-Trueba, Laura ; Thomson, Cameron R. ; Hansen, Uwe ; Lianos, Spyridonas ; Hazarika, Snoopy ; El Abdallah, Omar HMEH ; Ammar, Malak A. ; Cassels, Jennifer ; Michie, Alison M. ; Bulleid, Neil J. ; Malfait, Fransiska ; Van Agtmael, Tom
Publisher:London: Nature Publishing Group UK
Journal title:Cell death discovery, 2025-04, Vol.11 (1), p.200-11, Article 200
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Correction: The chemical chaperone 4-phenylbutyric acid rescues molecular cell defects of COL3A1 mutations that cause vascular Ehlers Danlos Syndrome
Author / Creator:Omar, Ramla ; Lee, Michelle AW ; Gonzalez-Trueba, Laura ; Thomson, Cameron R. ; Hansen, Uwe ; Lianos, Spyridonas ; Hazarika, Snoopy ; El Abdallah, Omar HMEH ; Ammar, Malak A. ; Cassels, Jennifer ; Michie, Alison M. ; Bulleid, Neil J. ; Malfait, Fransiska ; Van Agtmael, Tom
Publisher:London: Nature Publishing Group UK
Journal title:Cell death discovery, 2025-05, Vol.11 (1), p.250-1, Article 250
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ArticlesPeer ReviewedFull Text
Transcriptional Regulation by the NFAT Family in Acute Myeloid Leukaemia
Author / Creator:Patterson, Shaun D. ; Huang, Xu ; Jørgensen, Heather G. ; Michie, Alison M.
Publisher:Aviano: MDPI AG
Journal title:Hemato, 2021-09, Vol.2 (3), p.556-571
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Targeting quiescent leukemic stem cells using second generation autophagy inhibitors
Author / Creator:Baquero, Pablo ; Dawson, Amy ; Mukhopadhyay, Arunima ; Kuntz, Elodie M. ; Mitchell, Rebecca ; Olivares, Orianne ; Ianniciello, Angela ; Scott, Mary T. ; Dunn, Karen ; Nicastri, Michael C. ; Winkler, Jeffrey D. ; Michie, Alison M. ; Ryan, Kevin M. ; Halsey, Christina ; Gottlieb, Eyal ; Keaney, Erin P. ; Murphy, Leon O. ; Amaravadi, Ravi K. ; Holyoake, Tessa L. ; Helgason, G. Vignir
Publisher:London: Nature Publishing Group UK
Journal title:Leukemia, 2019-04, Vol.33 (4), p.981-994
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mTORC1-selective activation of translation elongation promotes disease progression in chronic lymphocytic leukemia
Author / Creator:Malik, Natasha ; Hay, Jodie ; Almuhanna, Hassan N. B. ; Dunn, Karen M. ; Lees, Jamie ; Cassels, Jennifer ; Li, Jiatian ; Nakagawa, Rinako ; Sansom, Owen J. ; Michie, Alison M.
Publisher:London: Nature Publishing Group UK
Journal title:Leukemia, 2023-12, Vol.37 (12), p.2414-2425
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A novel transgenic mouse strain expressing PKCβII demonstrates expansion of B1 and marginal zone B cell populations
Author / Creator:Azar, Ali A. ; Michie, Alison M. ; Tarafdar, Anuradha ; Malik, Natasha ; Menon, Geetha K. ; Till, Kathleen J. ; Vlatković, Nikolina ; Slupsky, Joseph R.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2020-08, Vol.10 (1), p.13156-13156, Article 13156
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PKCβ Facilitates Leukemogenesis in Chronic Lymphocytic Leukaemia by Promoting Constitutive BCR-Mediated Signalling
Author / Creator:Hay, Jodie ; Tarafdar, Anuradha ; Holroyd, Ailsa K. ; Moka, Hothri A. ; Dunn, Karen M. ; Alshayeb, Alzahra ; Lloyd, Bryony H. ; Cassels, Jennifer ; Malik, Natasha ; Khan, Ashfia F. ; Sou, IengFong ; Lees, Jamie ; Almuhanna, Hassan N. B. ; Kalakonda, Nagesh ; Slupsky, Joseph R. ; Michie, Alison M.
Publisher:Switzerland: MDPI AG
Journal title:Cancers, 2022-12, Vol.14 (23), p.6006
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Association of CNS involvement in childhood acute lymphoblastic leukaemia with cholesterol biosynthesis upregulation
Author / Creator:Cousins, Antony F, MBChB ; Olivares, Orianne, PhD ; Michie, Alison M, PhD ; Gottlieb, Eyal, PhD ; Halsey, Christina, Dr
Publisher:London: Elsevier Ltd
Journal title:The Lancet (British edition), 2017-02, Vol.389, p.S35-S35
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Allelic Exclusion and Differentiation by Protein Kinase C-Mediated Signals in Immature Thymocytes
Author / Creator:Michie, Alison M. ; Soh, Jae-Won ; Hawley, Robert G. ; Weinstein, I. Bernard ; Zúñiga-Pflücker, Juan Carlos
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2001-01, Vol.98 (2), p.609-614
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Determining the role of specific signaling molecules during lymphocyte development in vivo: instant transgenesis
Author / Creator:Nakagawa, Rinako ; Mason, Susan M ; Michie, Alison M
Publisher:London: Nature Publishing Group UK
Journal title:Nature protocols, 2006-09, Vol.1 (3), p.1185-1193
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mTORC1 activity is essential for disease progression in chronic lymphocytic leukemia
Author / Creator:Malik, Natasha ; Hay, Jodie ; Dunn, Karen M ; Nakagawa, Rinako ; Sansom, Owen J ; Michie, Alison M
Publisher:Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title:bioRxiv, 2022-04
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Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells

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Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells

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Activating p53 abolishes self-renewal of quiescent leukaemic stem cells in residual CML disease

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The MYC–NFATC2 axis maintains the cell cycle and mitochondrial function in acute myeloid leukaemia cells

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Bioengineered niches that recreate physiological extracellular matrix organisation to support long-term haematopoietic stem cells

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A KDM4A-PAF1-mediated epigenomic network is essential for acute myeloid leukemia cell self-renewal and survival

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mTORC1 activity is essential for erythropoiesis and B cell lineage commitment

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Nfix Expression Critically Modulates Early B Lymphopoiesis and Myelopoiesis

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Dasatinib Inhibits CXCR4 Signaling in Chronic Lymphocytic Leukaemia Cells and Impairs Migration Towards CXCL12

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The chemical chaperone 4-phenylbutyric acid rescues molecular cell defects of COL3A1 mutations that cause vascular Ehlers Danlos Syndrome

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Correction: The chemical chaperone 4-phenylbutyric acid rescues molecular cell defects of COL3A1 mutations that cause vascular Ehlers Danlos Syndrome

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Transcriptional Regulation by the NFAT Family in Acute Myeloid Leukaemia

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Targeting quiescent leukemic stem cells using second generation autophagy inhibitors

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mTORC1-selective activation of translation elongation promotes disease progression in chronic lymphocytic leukemia

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A novel transgenic mouse strain expressing PKCβII demonstrates expansion of B1 and marginal zone B cell populations

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PKCβ Facilitates Leukemogenesis in Chronic Lymphocytic Leukaemia by Promoting Constitutive BCR-Mediated Signalling

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Association of CNS involvement in childhood acute lymphoblastic leukaemia with cholesterol biosynthesis upregulation

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Allelic Exclusion and Differentiation by Protein Kinase C-Mediated Signals in Immature Thymocytes

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Determining the role of specific signaling molecules during lymphocyte development in vivo: instant transgenesis

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mTORC1 activity is essential for disease progression in chronic lymphocytic leukemia

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