Inhibitory synaptic transmission is impaired at higher extracellular Ca2+ concentrations in Scn1a+/−...
Inhibitory synaptic transmission is impaired at higher extracellular Ca2+ concentrations in Scn1a+/− mouse model of Dravet syndrome
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Dravet syndrome (DS) is an intractable form of childhood epilepsy that occurs in infancy. More than 80% of all patients have a heterozygous abnormality in the
SCN1A
gene, which encodes a subunit of Na
+
channels in the brain. However, the detailed pathogenesis of DS remains unclear. This study investigated the synaptic pathogenesis of t...
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Inhibitory synaptic transmission is impaired at higher extracellular Ca2+ concentrations in Scn1a+/− mouse model of Dravet syndrome
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TN_cdi_doaj_primary_oai_doaj_org_article_f6e6c8cce3c4492e8c1aea934931d3d8
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f6e6c8cce3c4492e8c1aea934931d3d8
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-021-90224-4
