Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between comple...
Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases
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Full title
Author / Creator
Blue Mountains Eye Study—GWAS group , NEIGHBORHOOD Consortium , Wellcome Trust Case Control Consortium 2 (WTCCC2) , Iglesias, Adriana I. , Mishra, Aniket , Vitart, Veronique , Bykhovskaya, Yelena , Höhn, René , Springelkamp, Henriët , Cuellar-Partida, Gabriel , Gharahkhani, Puya , Bailey, Jessica N. Cooke , Willoughby, Colin E. , Li, Xiaohui , Yazar, Seyhan , Nag, Abhishek , Khawaja, Anthony P. , Polašek, Ozren , Siscovick, David , Mitchell, Paul , Tham, Yih Chung , Haines, Jonathan L. , Kearns, Lisa S. , Hayward, Caroline , Shi, Yuan , van Leeuwen, Elisabeth M. , Taylor, Kent D. , Bonnemaijer, Pieter , Rotter, Jerome I. , Martin, Nicholas G. , Zeller, Tanja , Mills, Richard A. , Souzeau, Emmanuelle , Staffieri, Sandra E. , Jonas, Jost B. , Schmidtmann, Irene , Boutin, Thibaud , Kang, Jae H. , Lucas, Sionne E. M. , Wong, Tien Yin , Beutel, Manfred E. , Wilson, James F. , Uitterlinden, André G. , Vithana, Eranga N. , Foster, Paul J. , Hysi, Pirro G. , Hewitt, Alex W. , Khor, Chiea Chuen , Pasquale, Louis R. , Montgomery, Grant W. , Klaver, Caroline C. W. , Aung, Tin , Pfeiffer, Norbert , Mackey, David A. , Hammond, Christopher J. , Cheng, Ching-Yu , Craig, Jamie E. , Rabinowitz, Yaron S. , Wiggs, Janey L. , Burdon, Kathryn P. , van Duijn, Cornelia M. and MacGregor, Stuart
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide association meta-analysis of CCT and identify 19 novel regions. In addition to adding support for known connective tissue-related pathways, pathway analyses uncover previously unreported gene se...
Alternative Titles
Full title
Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases
Authors, Artists and Contributors
Author / Creator
NEIGHBORHOOD Consortium
Wellcome Trust Case Control Consortium 2 (WTCCC2)
Iglesias, Adriana I.
Mishra, Aniket
Vitart, Veronique
Bykhovskaya, Yelena
Höhn, René
Springelkamp, Henriët
Cuellar-Partida, Gabriel
Gharahkhani, Puya
Bailey, Jessica N. Cooke
Willoughby, Colin E.
Li, Xiaohui
Yazar, Seyhan
Nag, Abhishek
Khawaja, Anthony P.
Polašek, Ozren
Siscovick, David
Mitchell, Paul
Tham, Yih Chung
Haines, Jonathan L.
Kearns, Lisa S.
Hayward, Caroline
Shi, Yuan
van Leeuwen, Elisabeth M.
Taylor, Kent D.
Bonnemaijer, Pieter
Rotter, Jerome I.
Martin, Nicholas G.
Zeller, Tanja
Mills, Richard A.
Souzeau, Emmanuelle
Staffieri, Sandra E.
Jonas, Jost B.
Schmidtmann, Irene
Boutin, Thibaud
Kang, Jae H.
Lucas, Sionne E. M.
Wong, Tien Yin
Beutel, Manfred E.
Wilson, James F.
Uitterlinden, André G.
Vithana, Eranga N.
Foster, Paul J.
Hysi, Pirro G.
Hewitt, Alex W.
Khor, Chiea Chuen
Pasquale, Louis R.
Montgomery, Grant W.
Klaver, Caroline C. W.
Aung, Tin
Pfeiffer, Norbert
Mackey, David A.
Hammond, Christopher J.
Cheng, Ching-Yu
Craig, Jamie E.
Rabinowitz, Yaron S.
Wiggs, Janey L.
Burdon, Kathryn P.
van Duijn, Cornelia M.
MacGregor, Stuart
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_f7334f0a8f8b42b18a3180c2a6650fb9
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f7334f0a8f8b42b18a3180c2a6650fb9
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-03646-6
