Ultraconserved element uc.372 drives hepatic lipid accumulation by suppressing miR-195/miR4668 matur...
Ultraconserved element uc.372 drives hepatic lipid accumulation by suppressing miR-195/miR4668 maturation
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Author / Creator
Guo, Jun , Fang, Weiwei , Sun, Libo , Lu, Yonggang , Dou, Lin , Huang, Xiuqing , Tang, Weiqing , Yu, Liqing and Li, Jian
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Ultraconserved (uc) RNAs, a class of long non-coding RNAs (lncRNAs), are conserved across humans, mice, and rats, but the physiological significance and pathological role of ucRNAs is largely unknown. Here we show that uc.372 is upregulated in the livers of db/db mice, HFD-fed mice, and NAFLD patients. Gain-of-function and loss-of-function studies...
Alternative Titles
Full title
Ultraconserved element uc.372 drives hepatic lipid accumulation by suppressing miR-195/miR4668 maturation
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_f7ca35753a8e4489875426859f45a85a
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f7ca35753a8e4489875426859f45a85a
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-03072-8
