Gain-of-function cardiomyopathic mutations in RBM20 rewire splicing regulation and re-distribute rib...
Gain-of-function cardiomyopathic mutations in RBM20 rewire splicing regulation and re-distribute ribonucleoprotein granules within processing bodies
About this item
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Author / Creator
Fenix, Aidan M. , Miyaoka, Yuichiro , Bertero, Alessandro , Blue, Steven M. , Spindler, Matthew J. , Tan, Kenneth K. B. , Perez-Bermejo, Juan A. , Chan, Amanda H. , Mayerl, Steven J. , Nguyen, Trieu D. , Russell, Caitlin R. , Lizarraga, Paweena P. , Truong, Annie , So, Po-Lin , Kulkarni, Aishwarya , Chetal, Kashish , Sathe, Shashank , Sniadecki, Nathan J. , Yeo, Gene W. , Murry, Charles E. , Conklin, Bruce R. and Salomonis, Nathan
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Mutations in the cardiac splicing factor RBM20 lead to malignant dilated cardiomyopathy (DCM). To understand the mechanism of RBM20-associated DCM, we engineered isogenic iPSCs with DCM-associated missense mutations in RBM20 as well as RBM20 knockout (KO) iPSCs. iPSC-derived engineered heart tissues made from these cell lines recapitulate contracti...
Alternative Titles
Full title
Gain-of-function cardiomyopathic mutations in RBM20 rewire splicing regulation and re-distribute ribonucleoprotein granules within processing bodies
Authors, Artists and Contributors
Author / Creator
Miyaoka, Yuichiro
Bertero, Alessandro
Blue, Steven M.
Spindler, Matthew J.
Tan, Kenneth K. B.
Perez-Bermejo, Juan A.
Chan, Amanda H.
Mayerl, Steven J.
Nguyen, Trieu D.
Russell, Caitlin R.
Lizarraga, Paweena P.
Truong, Annie
So, Po-Lin
Kulkarni, Aishwarya
Chetal, Kashish
Sathe, Shashank
Sniadecki, Nathan J.
Yeo, Gene W.
Murry, Charles E.
Conklin, Bruce R.
Salomonis, Nathan
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_f87c8729e80949bda7d8b7b816b64084
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f87c8729e80949bda7d8b7b816b64084
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-26623-y
