SGN-B7H4V, an investigational vedotin ADC directed to the immune checkpoint ligand B7-H4, shows prom...
SGN-B7H4V, an investigational vedotin ADC directed to the immune checkpoint ligand B7-H4, shows promising activity in preclinical models
About this item
Full title
Author / Creator
Gray, Elizabeth , Ulrich, Michelle , Epp, Angela , Younan, Patrick , Sahetya, Disha , Hensley, Kelly , Allred, Sean , Huang, Li-Ya , Hahn, Julie , Gahnberg, Kristen , Treuting, Piper M , Trueblood, Esther S , Gosink, John J , Thurman, Robert , Wo, Serena , Spahr, Kellie , Haass, Evgenia Jane , Snead, Katie , Miller, Dannah , Padilla, Mary , Smith, Alyson J , Frantz, Chris , Schrum, Jason P , Nazarenko, Natalya and Gardai, Shyra J
Publisher
London: BMJ Publishing Group Ltd
Journal title
Language
English
Formats
Publication information
Publisher
London: BMJ Publishing Group Ltd
Subjects
More information
Scope and Contents
Contents
BackgroundSGN-B7H4V is a novel investigational vedotin antibody–drug conjugate (ADC) comprising a B7-H4-directed human monoclonal antibody conjugated to the cytotoxic payload monomethyl auristatin E (MMAE) via a protease-cleavable maleimidocaproyl valine citrulline (mc-vc) linker. This vedotin linker-payload system has been clinically validated in...
Alternative Titles
Full title
SGN-B7H4V, an investigational vedotin ADC directed to the immune checkpoint ligand B7-H4, shows promising activity in preclinical models
Authors, Artists and Contributors
Author / Creator
Ulrich, Michelle
Epp, Angela
Younan, Patrick
Sahetya, Disha
Hensley, Kelly
Allred, Sean
Huang, Li-Ya
Hahn, Julie
Gahnberg, Kristen
Treuting, Piper M
Trueblood, Esther S
Gosink, John J
Thurman, Robert
Wo, Serena
Spahr, Kellie
Haass, Evgenia Jane
Snead, Katie
Miller, Dannah
Padilla, Mary
Smith, Alyson J
Frantz, Chris
Schrum, Jason P
Nazarenko, Natalya
Gardai, Shyra J
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_f885976e5e104e04a8016c6dbb713fb4
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f885976e5e104e04a8016c6dbb713fb4
Other Identifiers
ISSN
2051-1426
E-ISSN
2051-1426
DOI
10.1136/jitc-2023-007572
