Huntington’s disease cellular phenotypes are rescued non-cell autonomously by healthy cells in mosai...
Huntington’s disease cellular phenotypes are rescued non-cell autonomously by healthy cells in mosaic telencephalic organoids
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Full title
Author / Creator
Galimberti, Maura , Nucera, Maria R. , Bocchi, Vittoria D. , Conforti, Paola , Vezzoli, Elena , Cereda, Matteo , Maffezzini, Camilla , Iennaco, Raffaele , Scolz, Andrea , Falqui, Andrea , Cordiglieri, Chiara , Cremona, Martina , Espuny-Camacho, Ira , Faedo, Andrea , Felsenfeld, Dan P. , Vogt, Thomas F. , Ranzani, Valeria , Zuccato, Chiara , Besusso, Dario and Cattaneo, Elena
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Huntington’s disease (HD) causes selective degeneration of striatal and cortical neurons, resulting in cell mosaicism of coexisting still functional and dysfunctional cells. The impact of non-cell autonomous mechanisms between these cellular states is poorly understood. Here we generated telencephalic organoids with healthy or HD cells, grown separ...
Alternative Titles
Full title
Huntington’s disease cellular phenotypes are rescued non-cell autonomously by healthy cells in mosaic telencephalic organoids
Authors, Artists and Contributors
Author / Creator
Nucera, Maria R.
Bocchi, Vittoria D.
Conforti, Paola
Vezzoli, Elena
Cereda, Matteo
Maffezzini, Camilla
Iennaco, Raffaele
Scolz, Andrea
Falqui, Andrea
Cordiglieri, Chiara
Cremona, Martina
Espuny-Camacho, Ira
Faedo, Andrea
Felsenfeld, Dan P.
Vogt, Thomas F.
Ranzani, Valeria
Zuccato, Chiara
Besusso, Dario
Cattaneo, Elena
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_f886204e00154c1a8e03cf3cdc9d56ff
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f886204e00154c1a8e03cf3cdc9d56ff
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-50877-x
