PRRX1 is a master transcription factor of stromal fibroblasts for myofibroblastic lineage progressio...
PRRX1 is a master transcription factor of stromal fibroblasts for myofibroblastic lineage progression
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Contents
Although stromal fibroblasts play a critical role in cancer progression, their identities remain unclear as they exhibit high heterogeneity and plasticity. Here, a master transcription factor (mTF) constructing core-regulatory circuitry,
PRRX1
, which determines the fibroblast lineage with a myofibroblastic phenotype, is identified for the fi...
Alternative Titles
Full title
PRRX1 is a master transcription factor of stromal fibroblasts for myofibroblastic lineage progression
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TN_cdi_doaj_primary_oai_doaj_org_article_f8a3db8d4f924585bc63f79a50a42110
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f8a3db8d4f924585bc63f79a50a42110
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-30484-4
