Targeted ASO-mediated Atp1a2 knockdown in astrocytes reduces SOD1 aggregation and accelerates diseas...
Targeted ASO-mediated Atp1a2 knockdown in astrocytes reduces SOD1 aggregation and accelerates disease onset in mutant SOD1 mice
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San Francisco, CA USA: Public Library of Science
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English
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San Francisco, CA USA: Public Library of Science
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Astrocyte-specific ion pump [alpha]2-Na.sup.+ /K.sup.+ -ATPase plays a critical role in the pathogenesis of amyotrophic lateral sclerosis (ALS). Here, we test the effect of Atp1a2 mRNA-specific antisense oligonucleotides (ASOs) to induce [alpha]2-Na.sup.+ /K.sup.+ -ATPase knockdown in the widely used ALS animal model, SOD1*G93A mice. Two ASOs led t...
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Targeted ASO-mediated Atp1a2 knockdown in astrocytes reduces SOD1 aggregation and accelerates disease onset in mutant SOD1 mice
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TN_cdi_doaj_primary_oai_doaj_org_article_fa5a7e541e4d4505993eefd9b7fb29a9
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fa5a7e541e4d4505993eefd9b7fb29a9
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0294731
