Cas9-specific immune responses compromise local and systemic AAV CRISPR therapy in multiple dystroph...
Cas9-specific immune responses compromise local and systemic AAV CRISPR therapy in multiple dystrophic canine models
About this item
Full title
Author / Creator
Hakim, Chady H. , Kumar, Sandeep R. P. , Pérez-López, Dennis O. , Wasala, Nalinda B. , Zhang, Dong , Yue, Yongping , Teixeira, James , Pan, Xiufang , Zhang, Keqing , Million, Emily D. , Nelson, Christopher E. , Metzger, Samantha , Han, Jin , Louderman, Jacqueline A. , Schmidt, Florian , Feng, Feng , Grimm, Dirk , Smith, Bruce F. , Yao, Gang , Yang, N. Nora , Gersbach, Charles A. , Chen, Shi-jie , Herzog, Roland W. and Duan, Dongsheng
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Adeno-associated virus (AAV)-mediated CRISPR-Cas9 editing holds promise to treat many diseases. The immune response to bacterial-derived Cas9 has been speculated as a hurdle for AAV-CRISPR therapy. However, immunological consequences of AAV-mediated Cas9 expression have thus far not been thoroughly investigated in large mammals. We evaluate Cas9-sp...
Alternative Titles
Full title
Cas9-specific immune responses compromise local and systemic AAV CRISPR therapy in multiple dystrophic canine models
Authors, Artists and Contributors
Author / Creator
Kumar, Sandeep R. P.
Pérez-López, Dennis O.
Wasala, Nalinda B.
Zhang, Dong
Yue, Yongping
Teixeira, James
Pan, Xiufang
Zhang, Keqing
Million, Emily D.
Nelson, Christopher E.
Metzger, Samantha
Han, Jin
Louderman, Jacqueline A.
Schmidt, Florian
Feng, Feng
Grimm, Dirk
Smith, Bruce F.
Yao, Gang
Yang, N. Nora
Gersbach, Charles A.
Chen, Shi-jie
Herzog, Roland W.
Duan, Dongsheng
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_fa789cec57864e868cf64db8cae359c5
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fa789cec57864e868cf64db8cae359c5
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-26830-7
