Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis
Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis
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Author / Creator
Ruhland, Megan K. , Loza, Andrew J. , Capietto, Aude-Helene , Luo, Xianmin , Knolhoff, Brett L. , Flanagan, Kevin C. , Belt, Brian A. , Alspach, Elise , Leahy, Kathleen , Luo, Jingqin , Schaffer, Andras , Edwards, John R. , Longmore, Gregory , Faccio, Roberta , DeNardo, David G. and Stewart, Sheila A.
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Age is a significant risk factor for the development of cancer. However, the mechanisms that drive age-related increases in cancer remain poorly understood. To determine if senescent stromal cells influence tumorigenesis, we develop a mouse model that mimics the aged skin microenvironment. Using this model, here we find that senescent stromal cells...
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Full title
Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis
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TN_cdi_doaj_primary_oai_doaj_org_article_fa867a0d00a840c499859677d3888265
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fa867a0d00a840c499859677d3888265
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms11762
