Fc-engineered large molecules targeting blood-brain barrier transferrin receptor and CD98hc have dis...
Fc-engineered large molecules targeting blood-brain barrier transferrin receptor and CD98hc have distinct central nervous system and peripheral biodistribution
About this item
Full title
Author / Creator
Khoury, Nathalie , Pizzo, Michelle E. , Discenza, Claire B. , Joy, David , Tatarakis, David , Todorov, Mihail Ivilinov , Negwer, Moritz , Ha, Connie , De Melo, Gabrielly L. , Sarrafha, Lily , Simon, Matthew J. , Chan, Darren , Chau, Roni , Chew, Kylie S. , Chow, Johann , Clemens, Allisa , Robles-Colmenares, Yaneth , Dugas, Jason C. , Duque, Joseph , Kaltenecker, Doris , Kane, Holly , Leung, Amy , Lozano, Edwin , Moshkforoush, Arash , Roche, Elysia , Sandmann, Thomas , Tong, Mabel , Xa, Kaitlin , Zhou, Yinhan , Lewcock, Joseph W. , Ertürk, Ali , Thorne, Robert G. , Calvert, Meredith E. K. and Yu Zuchero, Y. Joy
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Blood brain barrier-crossing molecules targeting transferrin receptor (TfR) and CD98 heavy chain (CD98hc) are widely reported to promote enhanced brain delivery of therapeutics. Here, we provide a comprehensive and unbiased biodistribution characterization of TfR and CD98hc antibody transport vehicles (ATV
TfR
and ATV
CD98hc
) compared...
Alternative Titles
Full title
Fc-engineered large molecules targeting blood-brain barrier transferrin receptor and CD98hc have distinct central nervous system and peripheral biodistribution
Authors, Artists and Contributors
Author / Creator
Pizzo, Michelle E.
Discenza, Claire B.
Joy, David
Tatarakis, David
Todorov, Mihail Ivilinov
Negwer, Moritz
Ha, Connie
De Melo, Gabrielly L.
Sarrafha, Lily
Simon, Matthew J.
Chan, Darren
Chau, Roni
Chew, Kylie S.
Chow, Johann
Clemens, Allisa
Robles-Colmenares, Yaneth
Dugas, Jason C.
Duque, Joseph
Kaltenecker, Doris
Kane, Holly
Leung, Amy
Lozano, Edwin
Moshkforoush, Arash
Roche, Elysia
Sandmann, Thomas
Tong, Mabel
Xa, Kaitlin
Zhou, Yinhan
Lewcock, Joseph W.
Ertürk, Ali
Thorne, Robert G.
Calvert, Meredith E. K.
Yu Zuchero, Y. Joy
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_faab7d7d7e034d658e971277314aa2fe
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_faab7d7d7e034d658e971277314aa2fe
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-025-57108-x
