Schwann cell nodal membrane disruption triggers bystander axonal degeneration in a Guillain-Barré sy...
Schwann cell nodal membrane disruption triggers bystander axonal degeneration in a Guillain-Barré syndrome mouse model
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United States: American Society for Clinical Investigation
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Language
English
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Publisher
United States: American Society for Clinical Investigation
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In Guillain-Barré syndrome (GBS), both axonal and demyelinating variants can be mediated by complement-fixing anti-GM1 ganglioside autoantibodies that target peripheral nerve axonal and Schwann cell (SC) membranes, respectively. Critically, the extent of axonal degeneration in both variants dictates long-term outcome. The differing pathomechanisms...
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Full title
Schwann cell nodal membrane disruption triggers bystander axonal degeneration in a Guillain-Barré syndrome mouse model
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TN_cdi_doaj_primary_oai_doaj_org_article_fb1eb71fa73646e493bb351632034731
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fb1eb71fa73646e493bb351632034731
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ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI158524
