USP13 negatively regulates antiviral responses by deubiquitinating STING
USP13 negatively regulates antiviral responses by deubiquitinating STING
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Author / Creator
Sun, He , Zhang, Qiang , Jing, Ying-Ying , Zhang, Man , Wang, Hai-Ying , Cai, Zeng , Liuyu, Tianzi , Zhang, Zhi-Dong , Xiong, Tian-Chen , Wu, Yan , Zhu, Qi-Yun , Yao, Jing , Shu, Hong-Bing , Lin, Dandan and Zhong, Bo
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
STING (also known as MITA) is critical for host defence against viruses and the activity of STING is regulated by ubiquitination. However, the deubiquitination of STING is not fully understood. Here, we show that ubiquitin-specific protease 13 (USP13) is a STING-interacting protein that catalyses deubiquitination of STING. Knockdown or knockout of...
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Full title
USP13 negatively regulates antiviral responses by deubiquitinating STING
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TN_cdi_doaj_primary_oai_doaj_org_article_fbc5fe9e9ef2487986b6042fd5305778
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fbc5fe9e9ef2487986b6042fd5305778
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms15534
