Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson’s disease in midbr...
Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson’s disease in midbrain dopaminergic neurons
About this item
Full title
Author / Creator
Virdi, Gurvir S. , Choi, Minee L. , Evans, James R. , Yao, Zhi , Athauda, Dilan , Strohbuecker, Stephanie , Nirujogi, Raja S. , Wernick, Anna I. , Pelegrina-Hidalgo, Noelia , Leighton, Craig , Saleeb, Rebecca S. , Kopach, Olga , Alrashidi, Haya , Melandri, Daniela , Perez-Lloret, Jimena , Angelova, Plamena R. , Sylantyev, Sergiy , Eaton, Simon , Heales, Simon , Rusakov, Dmitri A. , Alessi, Dario R. , Kunath, Tilo , Horrocks, Mathew H. , Abramov, Andrey Y. , Patani, Rickie and Gandhi, Sonia
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Mutations in the
SNCA
gene cause autosomal dominant Parkinson’s disease (PD), with loss of dopaminergic neurons in the substantia nigra, and aggregation of α-synuclein. The sequence of molecular events that proceed from an
SNCA
mutation during development, to end-stage pathology is unknown. Utilising human-induced pluripotent stem cells...
Alternative Titles
Full title
Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson’s disease in midbrain dopaminergic neurons
Authors, Artists and Contributors
Author / Creator
Choi, Minee L.
Evans, James R.
Yao, Zhi
Athauda, Dilan
Strohbuecker, Stephanie
Nirujogi, Raja S.
Wernick, Anna I.
Pelegrina-Hidalgo, Noelia
Leighton, Craig
Saleeb, Rebecca S.
Kopach, Olga
Alrashidi, Haya
Melandri, Daniela
Perez-Lloret, Jimena
Angelova, Plamena R.
Sylantyev, Sergiy
Eaton, Simon
Heales, Simon
Rusakov, Dmitri A.
Alessi, Dario R.
Kunath, Tilo
Horrocks, Mathew H.
Abramov, Andrey Y.
Patani, Rickie
Gandhi, Sonia
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_fc1ba7fa6d614cbe962ce2b5a05c4fa6
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fc1ba7fa6d614cbe962ce2b5a05c4fa6
Other Identifiers
ISSN
2373-8057
E-ISSN
2373-8057
DOI
10.1038/s41531-022-00423-7
