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ArticlesPeer ReviewedFull Text
LRRK2 kinase in Parkinson's disease
Author / Creator:Alessi, Dario R. ; Sammler, Esther
Publisher:United States: The American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2018-04, Vol.360 (6384), p.36-37
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Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation
Author / Creator:Maniaci, Chiara ; Hughes, Scott J. ; Testa, Andrea ; Chen, Wenzhang ; Lamont, Douglas J. ; Rocha, Sonia ; Alessi, Dario R. ; Romeo, Roberto ; Ciulli, Alessio
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-10, Vol.8 (1), p.830-14, Article 830
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LKB1 and AMPK and the cancer-metabolism link - ten years after
Author / Creator:Hardie, D Grahame ; Alessi, Dario R
Publisher:England: BioMed Central Ltd
Journal title:BMC biology, 2013-04, Vol.11 (1), p.36-36, Article 36
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Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis
Author / Creator:Steger, Martin ; Diez, Federico ; Dhekne, Herschel S ; Lis, Pawel ; Nirujogi, Raja S ; Karayel, Ozge ; Tonelli, Francesca ; Martinez, Terina N ; Lorentzen, Esben ; Pfeffer, Suzanne R ; Alessi, Dario R ; Mann, Matthias
Publisher:England: eLife Sciences Publications Ltd
Journal title:eLife, 2017-11, Vol.6
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A pathway for Parkinson’s Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain
Author / Creator:Dhekne, Herschel S ; Yanatori, Izumi ; Gomez, Rachel C ; Tonelli, Francesca ; Diez, Federico ; Schüle, Birgitt ; Steger, Martin ; Alessi, Dario R ; Pfeffer, Suzanne R
Publisher:England: eLife Science Publications, Ltd
Journal title:eLife, 2018-11, Vol.7
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Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases
Author / Creator:Steger, Martin ; Tonelli, Francesca ; Ito, Genta ; Davies, Paul ; Trost, Matthias ; Vetter, Melanie ; Wachter, Stefanie ; Lorentzen, Esben ; Duddy, Graham ; Wilson, Stephen ; Baptista, Marco AS ; Fiske, Brian K ; Fell, Matthew J ; Morrow, John A ; Reith, Alastair D ; Alessi, Dario R ; Mann, Matthias
Publisher:England: eLife Science Publications, Ltd
Journal title:eLife, 2016-01, Vol.5
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The IkappaB Kinase Family Phosphorylates the Parkinson’s Disease Kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor Signaling
Author / Creator:Dzamko, Nicolas ; Inesta-Vaquera, Francisco ; Zhang, Jiazhen ; Xie, Chengsong ; Cai, Huaibin ; Arthur, Simon ; Tan, Li ; Choi, Hwanguen ; Gray, Nathanael ; Cohen, Philip ; Pedrioli, Patrick ; Clark, Kristopher ; Alessi, Dario R.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2012-06, Vol.7 (6), p.e39132
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ArticlesPeer ReviewedFull Text
Crystal structure of the WD40 domain dimer of LRRK2
Author / Creator:Zhang, Pengfei ; Fan, Ying ; Ru, Heng ; Wang, Li ; Magupalli, Venkat Giri ; Taylor, Susan S. ; Alessi, Dario R. ; Wu, Hao
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2019-01, Vol.116 (5), p.1579-1584
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Screening of DUB activity and specificity by MALDI-TOF mass spectrometry
Author / Creator:Ritorto, Maria Stella ; Ewan, Richard ; Perez-Oliva, Ana B. ; Knebel, Axel ; Buhrlage, Sara J. ; Wightman, Melanie ; Kelly, Sharon M. ; Wood, Nicola T. ; Virdee, Satpal ; Gray, Nathanael S. ; Morrice, Nicholas A. ; Alessi, Dario R. ; Trost, Matthias
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2014-08, Vol.5 (1), p.4763, Article 4763
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ArticlesPeer ReviewedFull Text
Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2
Author / Creator:Deng, Xianming ; Dzamko, Nicolas ; Prescott, Alan ; Davies, Paul ; Liu, Qingsong ; Yang, Qingkai ; Lee, Jiing-Dwan ; Patricelli, Matthew P ; Nomanbhoy, Tyzoon K ; Alessi, Dario R ; Gray, Nathanael S
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2011-04, Vol.7 (4), p.203-205
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Activation of the renal Na⁺:Cl⁻ cotransporter by angiotensin II is a WNK4-dependent process
Author / Creator:Castañeda-Bueno, María ; Cervantes-Pérez, Luz Graciela ; Vázquez, Norma ; Uribe, Norma ; Kantesaria, Sheila ; Morla, Luciana ; Bobadilla, Norma A. ; Doucet, Alain ; Alessi, Dario R. ; Gamba, Gerardo
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2012-05, Vol.109 (20), p.7929-7934
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ArticlesPeer ReviewedFull Text
PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins
Author / Creator:Berndsen, Kerryn ; Lis, Pawel ; Yeshaw, Wondwossen M ; Wawro, Paulina S ; Nirujogi, Raja S ; Wightman, Melanie ; Macartney, Thomas ; Dorward, Mark ; Knebel, Axel ; Tonelli, Francesca ; Pfeffer, Suzanne R ; Alessi, Dario R
Publisher:England: eLife Sciences Publications Ltd
Journal title:eLife, 2019-10, Vol.8
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ArticlesPeer ReviewedFull Text
A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer
Author / Creator:Schönhuber, Nina ; Seidler, Barbara ; Schuck, Kathleen ; Veltkamp, Christian ; Schachtler, Christina ; Zukowska, Magdalena ; Eser, Stefan ; Feyerabend, Thorsten B ; Paul, Mariel C ; Eser, Philipp ; Klein, Sabine ; Lowy, Andrew M ; Banerjee, Ruby ; Yang, Fangtang ; Lee, Chang-Lung ; Moding, Everett J ; Kirsch, David G ; Scheideler, Angelika ; Alessi, Dario R ; Varela, Ignacio ; Bradley, Allan ; Kind, Alexander ; Schnieke, Angelika E ; Rodewald, Hans-Reimer ; Rad, Roland ; Schmid, Roland M ; Schneider, Günter ; Saur, Dieter
Publisher:London: Nature Publishing Group UK
Journal title:Nature medicine, 2014-11, Vol.20 (11), p.1340-1347
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Structure of the LKB1-STRAD-MO25 Complex Reveals an Allosteric Mechanism of Kinase Activation
Author / Creator:Zeqiraj, Elton ; Filippi, Beatrice Maria ; Deak, Maria ; Alessi, Dario R. ; van Aalten, Daan M. F.
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2009-12, Vol.326 (5960), p.1707-1711
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Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase
Author / Creator:Dhekne, Herschel S ; Tonelli, Francesca ; Yeshaw, Wondwossen M ; Chiang, Claire Y ; Limouse, Charles ; Jaimon, Ebsy ; Purlyte, Elena ; Alessi, Dario R ; Pfeffer, Suzanne R
Publisher:England: eLife Sciences Publications Ltd
Journal title:eLife, 2023-10, Vol.12
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A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation
Author / Creator:Vides, Edmundo G ; Adhikari, Ayan ; Chiang, Claire Y ; Lis, Pawel ; Purlyte, Elena ; Limouse, Charles ; Shumate, Justin L ; Spínola-Lasso, Elena ; Dhekne, Herschel S ; Alessi, Dario R ; Pfeffer, Suzanne R
Publisher:England: eLife Sciences Publications Ltd
Journal title:eLife, 2022-09, Vol.11
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MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases
Author / Creator:Filippi, Beatrice M ; de los Heros, Paola ; Mehellou, Youcef ; Navratilova, Iva ; Gourlay, Robert ; Deak, Maria ; Plater, Lorna ; Toth, Rachel ; Zeqiraj, Elton ; Alessi, Dario R
Publisher:Chichester, UK: John Wiley & Sons, Ltd
Journal title:The EMBO journal, 2011-05, Vol.30 (9), p.1730-1741
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Role of the WNK‐activated SPAK kinase in regulating blood pressure
Author / Creator:Rafiqi, Fatema H. ; Zuber, Annie Mercier ; Glover, Mark ; Richardson, Ciaran ; Fleming, Stewart ; Jovanović, Sofija ; Jovanović, Aleksandar ; O'Shaughnessy, Kevin M. ; Alessi, Dario R.
Publisher:London: Nature Publishing Group UK
Journal title:EMBO molecular medicine, 2010-02, Vol.2 (2), p.63-75
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Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway
Author / Creator:San-Cristobal, Pedro ; Pacheco-Alvarez, Diana ; Richardson, Ciaran ; Ring, Aaron M ; Vazquez, Norma ; Rafiqi, Fatema H ; Chari, Divya ; Kahle, Kristopher T ; Leng, Qiang ; Bobadilla, Norma A ; Hebert, Steven C ; Alessi, Dario R ; Lifton, Richard P ; Gamba, Gerardo
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2009-03, Vol.106 (11), p.4384-4389
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Regulation of membrane ruffling by polarized STIM1 and ORAI1 in cortactin-rich domains
Author / Creator:Lopez-Guerrero, Aida M. ; Tomas-Martin, Patricia ; Pascual-Caro, Carlos ; Macartney, Thomas ; Rojas-Fernandez, Alejandro ; Ball, Graeme ; Alessi, Dario R. ; Pozo-Guisado, Eulalia ; Martin-Romero, Francisco Javier
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2017-03, Vol.7 (1), p.383-383, Article 383
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Showing 1 to 20 of 104 results

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LRRK2 kinase in Parkinson's disease

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Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation

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LKB1 and AMPK and the cancer-metabolism link - ten years after

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Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis

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A pathway for Parkinson’s Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain

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Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

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The IkappaB Kinase Family Phosphorylates the Parkinson’s Disease Kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor Signaling

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Crystal structure of the WD40 domain dimer of LRRK2

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Screening of DUB activity and specificity by MALDI-TOF mass spectrometry

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Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2

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Activation of the renal Na⁺:Cl⁻ cotransporter by angiotensin II is a WNK4-dependent process

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PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins

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A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer

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Structure of the LKB1-STRAD-MO25 Complex Reveals an Allosteric Mechanism of Kinase Activation

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Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase

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A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation

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MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

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Role of the WNK‐activated SPAK kinase in regulating blood pressure

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Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway

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Regulation of membrane ruffling by polarized STIM1 and ORAI1 in cortactin-rich domains

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