Misfolded protein oligomers: mechanisms of formation, cytotoxic effects, and pharmacological approac...
Misfolded protein oligomers: mechanisms of formation, cytotoxic effects, and pharmacological approaches against protein misfolding diseases
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Publisher
England: BioMed Central Ltd
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Language
English
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England: BioMed Central Ltd
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Contents
The conversion of native peptides and proteins into amyloid aggregates is a hallmark of over 50 human disorders, including Alzheimer's and Parkinson's diseases. Increasing evidence implicates misfolded protein oligomers produced during the amyloid formation process as the primary cytotoxic agents in many of these devastating conditions. In this rev...
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Full title
Misfolded protein oligomers: mechanisms of formation, cytotoxic effects, and pharmacological approaches against protein misfolding diseases
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TN_cdi_doaj_primary_oai_doaj_org_article_fc5801f1b98b49f29a52e09a1075880f
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fc5801f1b98b49f29a52e09a1075880f
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ISSN
1750-1326
E-ISSN
1750-1326
DOI
10.1186/s13024-023-00651-2
