Novel DNA Aptamers that Bind to Mutant Huntingtin and Modify Its Activity
Novel DNA Aptamers that Bind to Mutant Huntingtin and Modify Its Activity
About this item
Full title
Author / Creator
Publisher
United States: Elsevier Inc
Journal title
Language
English
Formats
Publication information
Publisher
United States: Elsevier Inc
Subjects
More information
Scope and Contents
Contents
The CAG repeat expansion that elongates the polyglutamine tract in huntingtin is the root genetic cause of Huntington’s disease (HD), a debilitating neurodegenerative disorder. This seemingly slight change to the primary amino acid sequence alters the physical structure of the mutant protein and alters its activity. We have identified a set of G-qu...
Alternative Titles
Full title
Novel DNA Aptamers that Bind to Mutant Huntingtin and Modify Its Activity
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_fc7145233c5c473aaf6cd4dcf749ad7c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fc7145233c5c473aaf6cd4dcf749ad7c
Other Identifiers
ISSN
2162-2531
E-ISSN
2162-2531
DOI
10.1016/j.omtn.2018.03.008
