Attenuation of reverse transcriptase facilitates SAMHD1 restriction of HIV-1 in cycling cells
Attenuation of reverse transcriptase facilitates SAMHD1 restriction of HIV-1 in cycling cells
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England: BioMed Central Ltd
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English
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England: BioMed Central Ltd
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SAMHD1 is a deoxynucleotide triphosphohydrolase that restricts replication of HIV-1 in differentiated leucocytes. HIV-1 is not restricted in cycling cells and it has been proposed that this is due to phosphorylation of SAMHD1 at T592 in these cells inactivating the enzymatic activity. To distinguish between theories for how SAMHD1 restricts HIV-1 i...
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Attenuation of reverse transcriptase facilitates SAMHD1 restriction of HIV-1 in cycling cells
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TN_cdi_doaj_primary_oai_doaj_org_article_fcc2447b7cb84ebfa5ff96be2eb62e0d
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fcc2447b7cb84ebfa5ff96be2eb62e0d
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ISSN
1742-4690
E-ISSN
1742-4690
DOI
10.1186/s12977-023-00620-z
