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ArticlesPeer ReviewedFull Text
SAMHD1 restricts HIV-1 infection in resting CD4+ T cells
Author / Creator:Baldauf, Hanna-Mari ; Pan, Xiaoyu ; Erikson, Elina ; Schmidt, Sarah ; Daddacha, Waaqo ; Burggraf, Manja ; Schenkova, Kristina ; Ambiel, Ina ; Wabnitz, Guido ; Gramberg, Thomas ; Panitz, Sylvia ; Flory, Egbert ; Landau, Nathaniel R ; Sertel, Serkan ; Rutsch, Frank ; Lasitschka, Felix ; Kim, Baek ; König, Renate ; Fackler, Oliver T ; Keppler, Oliver T
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2012-11, Vol.18 (11), p.1682-1688
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SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4+T-cells
Author / Creator:Descours, Benjamin ; Cribier, Alexandra ; Chable-Bessia, Christine ; Ayinde, Diana ; Rice, Gillian ; Crow, Yanick ; Yatim, Ahmad ; Schwartz, Olivier ; Laguette, Nadine ; Benkirane, Monsef
Publisher:England: BioMed Central Ltd
Journal title:Retrovirology, 2012-10, Vol.9 (1), p.87-87, Article 87
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SAMHD1 Functions and Human Diseases
Author / Creator:Coggins, Si’Ana A. ; Mahboubi, Bijan ; Schinazi, Raymond F. ; Kim, Baek
Publisher:Switzerland: MDPI AG
Journal title:Viruses, 2020-03, Vol.12 (4), p.382
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SAMHD1 acts at stalled replication forks to prevent interferon induction
Author / Creator:Coquel, Flavie ; Silva, Maria-Joao ; Técher, Hervé ; Zadorozhny, Karina ; Sharma, Sushma ; Nieminuszczy, Jadwiga ; Mettling, Clément ; Dardillac, Elodie ; Barthe, Antoine ; Schmitz, Anne-Lyne ; Promonet, Alexy ; Cribier, Alexandra ; Sarrazin, Amélie ; Niedzwiedz, Wojciech ; Lopez, Bernard ; Costanzo, Vincenzo ; Krejci, Lumir ; Chabes, Andrei ; Benkirane, Monsef ; Lin, Yea-Lih ; Pasero, Philippe
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2018-05, Vol.557 (7703), p.57-61
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Substrates and Inhibitors of SAMHD1
Author / Creator:Hollenbaugh, Joseph A. ; Shelton, Jadd ; Tao, Sijia ; Amiralaei, Sheida ; Liu, Peng ; Lu, Xiao ; Goetze, Russell W. ; Zhou, Longhu ; Nettles, James H. ; Schinazi, Raymond F. ; Kim, Baek
Publisher:United States: Public Library of Science
Journal title:PloS one, 2017-01, Vol.12 (1), p.e0169052-e0169052
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SAMHD1 prevents autoimmunity by maintaining genome stability
Author / Creator:Kretschmer, Stefanie ; Wolf, Christine ; König, Nadja ; Staroske, Wolfgang ; Guck, Jochen ; Häusler, Martin ; Luksch, Hella ; Nguyen, Laura A ; Kim, Baek ; Alexopoulou, Dimitra ; Dahl, Andreas ; Rapp, Alexander ; Cardoso, M Cristina ; Shevchenko, Anna ; Lee-Kirsch, Min Ae
Publisher:England
Journal title:Annals of the rheumatic diseases, 2015-03, Vol.74 (3), p.e17-e17
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HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase
Author / Creator:Goldstone, David C. ; Ennis-Adeniran, Valerie ; Hedden, Joseph J. ; Groom, Harriet C. T. ; Rice, Gillian I. ; Christodoulou, Evangelos ; Walker, Philip A. ; Kelly, Geoff ; Haire, Lesley F. ; Yap, Melvyn W. ; de Carvalho, Luiz Pedro S. ; Stoye, Jonathan P. ; Crow, Yanick J. ; Taylor, Ian A. ; Webb, Michelle
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2011-12, Vol.480 (7377), p.379-382
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SAMHD1 in cancer: curse or cure?
Author / Creator:Schott, Kerstin ; Majer, Catharina ; Bulashevska, Alla ; Childs, Liam ; Schmidt, Mirko H. H. ; Rajalingam, Krishnaraj ; Munder, Markus ; König, Renate
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Journal of molecular medicine (Berlin, Germany), 2022-03, Vol.100 (3), p.351-372
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SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-κB and interferon pathways
Author / Creator:Chen, Shuliang ; Bonifati, Serena ; Qin, Zhihua ; St. Gelais, Corine ; Kodigepalli, Karthik M. ; Barrett, Bradley S. ; Kim, Sun Hee ; Antonucci, Jenna M. ; Ladner, Katherine J. ; Buzovetsky, Olga ; Knecht, Kirsten M. ; Xiong, Yong ; Yount, Jacob S. ; Guttridge, Denis C. ; Santiago, Mario L. ; Wu, Li
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2018-04, Vol.115 (16), p.E3798-E3807
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The ribonuclease activity of SAMHD1 is required for HIV-1 restriction
Author / Creator:Ryoo, Jeongmin ; Choi, Jongsu ; Oh, Changhoon ; Kim, Sungchul ; Seo, Minji ; Kim, Seok-Young ; Seo, Daekwan ; Kim, Jongkyu ; White, Tommy E ; Brandariz-Nuñez, Alberto ; Diaz-Griffero, Felipe ; Yun, Cheol-Heui ; Hollenbaugh, Joseph A ; Kim, Baek ; Baek, Daehyun ; Ahn, Kwangseog
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2014-08, Vol.20 (8), p.936-941
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SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx
Author / Creator:Laguette, Nadine ; Sobhian, Bijan ; Casartelli, Nicoletta ; Ringeard, Mathieu ; Chable-Bessia, Christine ; Ségéral, Emmanuel ; Yatim, Ahmad ; Emiliani, Stéphane ; Schwartz, Olivier ; Benkirane, Monsef
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2011-06, Vol.474 (7353), p.654-657
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SAMHD1 … and Viral Ways around It
Author / Creator:Deutschmann, Janina ; Gramberg, Thomas
Publisher:Switzerland: MDPI
Journal title:Viruses, 2021-03, Vol.13 (3), p.395
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Aicardi-Goutières syndrome-associated gene SAMHD1 preserves genome integrity by preventing R-loop formation at transcription–replication conflict regions
Author / Creator:Park, Kiwon ; Ryoo, Jeongmin ; Jeong, Heena ; Kim, Minsu ; Lee, Sungwon ; Hwang, Sung-Yeon ; Ahn, Jiyoung ; Kim, Doyeon ; Moon, Hyungseok C. ; Baek, Daehyun ; Kim, Kwangsoo ; Park, Hye Yoon ; Ahn, Kwangseog
Publisher:United States: Public Library of Science
Journal title:PLoS genetics, 2021-04, Vol.17 (4), p.e1009523-e1009523
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Heterozygous colon cancer-associated mutations of SAMHD1 have functional significance
Author / Creator:Rentoft, Matilda ; Lindell, Kristoffer ; Tran, Phong ; Chabes, Anna Lena ; Buckland, Robert J. ; Watt, Danielle L. ; Marjavaara, Lisette ; Nilsson, Anna Karin ; Melin, Beatrice ; Trygg, Johan ; Johansson, Erik ; Chabes, Andrei
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2016-04, Vol.113 (17), p.4723-4728
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deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells
Author / Creator:Franzolin, Elisa ; Pontarin, Giovanna ; Rampazzo, Chiara ; Miazzi, Cristina ; Ferraro, Paola ; Palumbo, Elisa ; Reichard, Peter ; Bianchi, Vera
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2013-08, Vol.110 (35), p.14272-14277
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Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1 , and ADAR : a case-control study
Author / Creator:Rice, Gillian I, PhD ; Forte, Gabriella M A, MPhil ; Szynkiewicz, Marcin, MSc ; Chase, Diana S, PhD ; Aeby, Alec, MD ; Abdel-Hamid, Mohamed S, MSc ; Ackroyd, Sam, MB ChB ; Allcock, Rebecca, FRCPath ; Bailey, Kathryn M, MRCPCH ; Balottin, Umberto, MD ; Barnerias, Christine, MD ; Bernard, Genevieve, MD ; Bodemer, Christine, PhD ; Botella, Maria P, MD ; Cereda, Cristina, PhD ; Chandler, Kate E, MD ; Dabydeen, Lyvia, MRCPCH ; Dale, Russell C, PhD ; De Laet, Corinne, MD ; De Goede, Christian G E L, FRCPCH ; del Toro, Mireia, MD ; Effat, Laila, PhD ; Enamorado, Noemi Nunez, MD ; Fazzi, Elisa, MD ; Gener, Blanca, MD ; Haldre, Madli, BSc ; Lin, Jean-Pierre S-M, PhD ; Livingston, John H, MB ChB ; Lourenco, Charles Marques, MD ; Marques, Wilson, MD ; Oades, Patrick, FRCPCH ; Peterson, Pärt, PhD ; Rasmussen, Magnhild, MD ; Roubertie, Agathe, MD ; Schmidt, Johanna Loewenstein, CGC ; Shalev, Stavit A, MD ; Simon, Rogelio, MD ; Spiegel, Ronen, MD ; Swoboda, Kathryn J, FACMG ; Temtamy, Samia A, PhD ; Vassallo, Grace, MD ; Vilain, Catheline N, MD ; Vogt, Julie, MRCP ; Wermenbol, Vanessa, MD ; Whitehouse, William P, FRCPCH ; Soler, Doriette, MD ; Olivieri, Ivana, MD ; Orcesi, Simona, MD ; Aglan, Mona S, PhD ; Zaki, Maha S, PhD ; Abdel-Salam, Ghada M H, PhD ; Vanderver, Adeline, MD ; Kisand, Kai, PhD ; Rozenberg, Flore, MD ; Lebon, Pierre, MD ; Crow, Yanick J, Prof
Publisher:England: Elsevier Ltd
Journal title:Lancet neurology, 2013-12, Vol.12 (12), p.1159-1169
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Restriction of diverse retroviruses by SAMHD1
Author / Creator:Gramberg, Thomas ; Kahle, Tanja ; Bloch, Nicolin ; Wittmann, Sabine ; Müllers, Erik ; Daddacha, Waaqo ; Hofmann, Henning ; Kim, Baek ; Lindemann, Dirk ; Landau, Nathaniel R
Publisher:England: BioMed Central Ltd
Journal title:Retrovirology, 2013-03, Vol.10 (1), p.26-26, Article 26
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Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein
Author / Creator:Hrecka, Kasia ; Hao, Caili ; Gierszewska, Magda ; Swanson, Selene K. ; Kesik-Brodacka, Malgorzata ; Srivastava, Smita ; Florens, Laurence ; Washburn, Michael P. ; Skowronski, Jacek
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2011-06, Vol.474 (7353), p.658-661
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SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+T-lymphocytes cannot be upregulated by interferons
Author / Creator:St Gelais, Corine ; de Silva, Suresh ; Amie, Sarah M ; Coleman, Christopher M ; Hoy, Heather ; Hollenbaugh, Joseph A ; Kim, Baek ; Wu, Li
Publisher:England: BioMed Central Ltd
Journal title:Retrovirology, 2012-12, Vol.9 (1), p.105-105, Article 105
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Ribonucleotide reductase inhibitors suppress SAMHD1 ara‐CTPase activity enhancing cytarabine efficacy
Author / Creator:Rudd, Sean G ; Tsesmetzis, Nikolaos ; Sanjiv, Kumar ; Paulin, Cynthia BJ ; Sandhow, Lakshmi ; Kutzner, Juliane ; Hed Myrberg, Ida ; Bunten, Sarah S ; Axelsson, Hanna ; Zhang, Si Min ; Rasti, Azita ; Mäkelä, Petri ; Coggins, Si'Ana A ; Tao, Sijia ; Suman, Sharda ; Branca, Rui M ; Mermelekas, Georgios ; Wiita, Elisée ; Lee, Sun ; Walfridsson, Julian ; Schinazi, Raymond F ; Kim, Baek ; Lehtiö, Janne ; Rassidakis, Georgios Z ; Pokrovskaja Tamm, Katja ; Warpman‐Berglund, Ulrika ; Heyman, Mats ; Grandér, Dan ; Lehmann, Sören ; Lundbäck, Thomas ; Qian, Hong ; Henter, Jan‐Inge ; Schaller, Torsten ; Helleday, Thomas ; Herold, Nikolas
Publisher:London: Nature Publishing Group UK
Journal title:EMBO molecular medicine, 2020-03, Vol.12 (3), p.e10419-n/a
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SAMHD1 restricts HIV-1 infection in resting CD4+ T cells

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SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4+T-cells

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SAMHD1 Functions and Human Diseases

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SAMHD1 acts at stalled replication forks to prevent interferon induction

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Substrates and Inhibitors of SAMHD1

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SAMHD1 prevents autoimmunity by maintaining genome stability

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HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

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SAMHD1 in cancer: curse or cure?

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SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-κB and interferon pathways

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The ribonuclease activity of SAMHD1 is required for HIV-1 restriction

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SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

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SAMHD1 … and Viral Ways around It

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Aicardi-Goutières syndrome-associated gene SAMHD1 preserves genome integrity by preventing R-loop formation at transcription–replication conflict regions

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Heterozygous colon cancer-associated mutations of SAMHD1 have functional significance

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deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells

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Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1 , and ADAR : a case-control study

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Restriction of diverse retroviruses by SAMHD1

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Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

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SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+T-lymphocytes cannot be upregulated by interferons

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Ribonucleotide reductase inhibitors suppress SAMHD1 ara‐CTPase activity enhancing cytarabine efficacy

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