Evaluation of levocetirizine in beagle dog and cynomolgus monkey telemetry assays: Defining the no Q...
Evaluation of levocetirizine in beagle dog and cynomolgus monkey telemetry assays: Defining the no QTc effect profile by timepoint and concentration‐QTc analysis
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United States: John Wiley & Sons, Inc
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English
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Publisher
United States: John Wiley & Sons, Inc
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In prior clinical studies, levocetirizine (LEVO) has demonstrated no effect on ventricular repolarization (QTc intervals), therefore it is a relevant negative control to assess in nonclinical assays to define low proarrhythmic risk. LEVO was tested in beagle dog and cynomolgus monkey (nonhuman primate [NHP]) telemetry models to understand the noncl...
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Full title
Evaluation of levocetirizine in beagle dog and cynomolgus monkey telemetry assays: Defining the no QTc effect profile by timepoint and concentration‐QTc analysis
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TN_cdi_doaj_primary_oai_doaj_org_article_fe1d85550ea34e519914111f52a7c714
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fe1d85550ea34e519914111f52a7c714
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ISSN
1752-8054
E-ISSN
1752-8062
DOI
10.1111/cts.13454
