ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis
ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Meiotic recombination is initiated by SPO11-induced double-strand breaks (DSBs). In most mammals, the methyltransferase PRDM9 guides SPO11 targeting, and the ATM kinase controls meiotic DSB numbers. Following MRE11 nuclease removal of SPO11, the DSB is resected and loaded with DMC1 filaments for homolog invasion. Here, we demonstrate the direct det...
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ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis
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TN_cdi_doaj_primary_oai_doaj_org_article_fe2f3dab8f70455daf145802e93451d5
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fe2f3dab8f70455daf145802e93451d5
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2041-1723
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2041-1723
DOI
10.1038/s41467-020-14654-w
