Stabilizing the closed SARS-CoV-2 spike trimer
Stabilizing the closed SARS-CoV-2 spike trimer
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The trimeric spike (S) protein of SARS-CoV-2 is the primary focus of most vaccine design and development efforts. Due to intrinsic instability typical of class I fusion proteins, S tends to prematurely refold to the post-fusion conformation, compromising immunogenic properties and prefusion trimer yields. To support ongoing vaccine development effo...
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Full title
Stabilizing the closed SARS-CoV-2 spike trimer
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TN_cdi_doaj_primary_oai_doaj_org_article_fef6c96d1aae41d7a61ebeb8f94b38a6
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fef6c96d1aae41d7a61ebeb8f94b38a6
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-20321-x
