Characterization and structure-based protein engineering of a regiospecific saponin acetyltransferas...
Characterization and structure-based protein engineering of a regiospecific saponin acetyltransferase from Astragalus membranaceus
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Author / Creator
Wang, Linlin , Jiang, Zhihui , Zhang, Jiahe , Chen, Kuan , Zhang, Meng , Wang, Zilong , Wang, Binju , Ye, Min and Qiao, Xue
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Acetylation contributes to the bioactivity of numerous medicinally important natural products. However, little is known about the acetylation on sugar moieties. Here we report a saponin acetyltransferase from
Astragalus membranaceus
. AmAT7-3 is discovered through a stepwise gene mining approach and characterized as the xylose C3′/C4′-
O
Alternative Titles
Full title
Characterization and structure-based protein engineering of a regiospecific saponin acetyltransferase from Astragalus membranaceus
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_ff52c7263f8141f18abb2b184e6aa97a
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ff52c7263f8141f18abb2b184e6aa97a
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-41599-7
