Pharmacological targeting of host chaperones protects from pertussis toxin in vitro and in vivo
Pharmacological targeting of host chaperones protects from pertussis toxin in vitro and in vivo
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Whooping cough is caused by
Bordetella pertussis
that releases pertussis toxin (PT) which comprises enzyme A-subunit PTS1 and binding/transport B-subunit. After receptor-mediated endocytosis, PT reaches the endoplasmic reticulum from where unfolded PTS1 is transported to the cytosol. PTS1 ADP-ribosylates G-protein α-subunits resulting in incr...
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Full title
Pharmacological targeting of host chaperones protects from pertussis toxin in vitro and in vivo
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TN_cdi_doaj_primary_oai_doaj_org_article_ffe6325e744642199e112ed599bf0f26
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ffe6325e744642199e112ed599bf0f26
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-021-84817-2
