Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation...
Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of α-synuclein, and apoptotic cell death in aged mice
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United States: National Academy of Sciences
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English
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United States: National Academy of Sciences
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Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease. LRRK2 is a large protein containing a small GTPase domain and a kinase domain, but its physiological role is unknown. To identify the normal function of LRRK2 in vivo, we generated two independent lines of germ-line deletion mice. The dopamin...
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Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of α-synuclein, and apoptotic cell death in aged mice
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TN_cdi_fao_agris_US201301847811
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_fao_agris_US201301847811
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0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1004676107
