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ArticlesPeer ReviewedFull Text
Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of α-synuclein, and apoptotic cell death in aged mice
Author / Creator:Tong, Youren ; Yamaguchi, Hiroo ; Giaime, Emilie ; Boyle, Scott ; Kopan, Raphael ; Kelleher, Raymond J. III ; Shen, Jie
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2010-05, Vol.107 (21), p.9879-9884
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ArticlesPeer ReviewedFull Text
Discovery of NV-5138, the first selective Brain mTORC1 activator
Author / Creator:Sengupta, Shomit ; Giaime, Emilie ; Narayan, Sridhar ; Hahm, Seung ; Howell, Jessica ; O’Neill, David ; Vlasuk, George P. ; Saiah, Eddine
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2019-03, Vol.9 (1), p.4107, Article 4107
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ArticlesPeer ReviewedFull Text
Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway
Author / Creator:Tong, Youren ; Giaime, Emilie ; Yamaguchi, Hiroo ; Ichimura, Takaharu ; Liu, Yumin ; Si, Huiqing ; Cai, Huaibin ; Bonventre, Joseph V ; Shen, Jie
Publisher:England: BioMed Central Ltd
Journal title:Molecular neurodegeneration, 2012-01, Vol.7 (1), p.2-2
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ArticlesPeer ReviewedFull Text
Loss of DJ-1 does not affect mitochondrial respiration but increases ROS production and mitochondrial permeability transition pore opening
Author / Creator:Giaime, Emilie ; Yamaguchi, Hiroo ; Gautier, Clement A ; Kitada, Tohru ; Shen, Jie
Publisher:United States: Public Library of Science
Journal title:PloS one, 2012-07, Vol.7 (7), p.e40501-e40501
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ArticlesPeer ReviewedFull Text
Huntington's disease phenotypes are improved via mTORC1 modulation by small molecule therapy
Author / Creator:Sophie St-Cyr ; Daniel D Child ; Emilie Giaime ; Alicia R Smith ; Christine J Pascua ; Seung Hahm ; Eddine Saiah ; Beverly L Davidson
Publisher:Public Library of Science (PLoS)
Journal title:PloS one, 2022-08, Vol.17 (8), p.e0273710
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ArticlesPeer ReviewedFull Text
Huntington’s disease phenotypes are improved via mTORC1 modulation by small molecule therapy
Author / Creator:St-Cyr, Sophie ; Child, Daniel D ; Giaime, Emilie ; Smith, Alicia R ; Pascua, Christine J ; Hahm, Seung ; Saiah, Eddine ; Davidson, Beverly L
Publisher:San Francisco: Public Library of Science
Journal title:PloS one, 2022-08, Vol.17 (8), p.e0273710-e0273710
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ArticlesPeer ReviewedFull Text
Regulation of mitochondrial permeability transition pore by PINK1
Author / Creator:Gautier, Clement A ; Giaime, Emilie ; Caballero, Erica ; Núñez, Lucía ; Song, Zhiyin ; Chan, David ; Villalobos, Carlos ; Shen, Jie
Publisher:England: BioMed Central Ltd
Journal title:Molecular neurodegeneration, 2012-05, Vol.7 (1), p.22-22, Article 22
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ArticlesPeer ReviewedFull Text
A chemical genetic approach to probe the function of PINK1 in regulating mitochondrial dynamics
Author / Creator:Zhang, Conggang ; Lee, Schuyler ; Peng, Yinghua ; Bunker, Eric ; Shen, Chong ; Giaime, Emilie ; Shen, Jie ; Shen, Jingshi ; Zhou, Zongyao ; Liu, Xuedong
Publisher:London: Nature Publishing Group UK
Journal title:Cell research, 2015-03, Vol.25 (3), p.394-397
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ArticlesPeer ReviewedFull Text
Regulation of mitochondrial function by PINK1, Parkin and DJ-1
Author / Creator:Giaime, Emilie ; Shen, Jie
Publisher:BioMed Central Ltd
Journal title:Molecular neurodegeneration, 2013-09, Vol.8 (S1), p.O13-O13, Article O13
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ArticlesPeer ReviewedFull Text
Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease
Author / Creator:da Costa, Cristine Alves ; Sunyach, Claire ; Giaime, Emilie ; West, Andrew ; Corti, Olga ; Brice, Alexis ; Safe, Stephen ; Abou-Sleiman, Patrick M. ; Wood, Nicholas W. ; Takahashi, Hitoshi ; Goldberg, Mathew S. ; Shen, Jie ; Checler, Frédéric
Publisher:London: Nature Publishing Group UK
Journal title:Nature cell biology, 2009-11, Vol.11 (11), p.1370-1375
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ArticlesPeer ReviewedFull Text
Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of [alpha]-synuclein, and apoptotic cell death in aged mice
Author / Creator:Tong, Youren ; Yamaguchi, Hiroo ; Giaime, Emilie ; Boyle, Scott ; Kopan, Raphael ; Kelleher, Raymond J ; Shen, Jie
Publisher:Washington: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2010-05, Vol.107 (21), p.9879
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ArticlesPeer ReviewedFull Text
Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of Î±-synuclein, and apoptotic cell death in aged mice
Author / Creator:Tong, Youren ; Yamaguchi, Hiroo ; Giaime, Emilie ; Boyle, Scott ; Kopan, Raphael ; Kelleher, Raymond J. III ; Shen, Jie
Publisher:National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2010, Vol.107 (21), p.9879-9884
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ArticlesPeer ReviewedFull Text
Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease
Author / Creator:Soehn, Anne S. ; Franck, Thomas ; Biskup, Saskia ; Giaime, Emilie ; Melle, Christian ; Rott, Ruth ; Cebo, Daniel ; Kalbacher, Hubert ; Ott, Erwin ; Pahnke, Jens ; Meitinger, Thomas ; Krüger, Rejko ; Gasser, Thomas ; Berg, Daniela ; von Eggeling, Ferdinand ; Engelender, Simone ; da Costa, Cristine Alves ; Riess, Olaf
Publisher:Berlin/Heidelberg: Springer-Verlag
Journal title:Neurogenetics, 2010-05, Vol.11 (2), p.203-215
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ArticlesPeer ReviewedFull Text
Study on the Putative Contribution of Caspases and the Proteasome to the Degradation of Aph-1a and Pen-2
Author / Creator:Dunys, Julie ; Kawarai, Toshitaka ; Giaime, Emilie ; Wilk, Sherwin ; Herrant, M. ; Auberger, P. ; St. George-Hyslop, Peter ; Alves da Costa, Cristine ; Checler, Frédéric
Publisher:Basel, Switzerland: S. Karger AG
Journal title:Neuro-degenerative diseases, 2007-01, Vol.4 (2-3), p.156-163
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Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of α-synuclein, and apoptotic cell death in aged mice

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Discovery of NV-5138, the first selective Brain mTORC1 activator

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Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway

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Loss of DJ-1 does not affect mitochondrial respiration but increases ROS production and mitochondrial permeability transition pore opening

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Huntington's disease phenotypes are improved via mTORC1 modulation by small molecule therapy

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Huntington’s disease phenotypes are improved via mTORC1 modulation by small molecule therapy

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Regulation of mitochondrial permeability transition pore by PINK1

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A chemical genetic approach to probe the function of PINK1 in regulating mitochondrial dynamics

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Regulation of mitochondrial function by PINK1, Parkin and DJ-1

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Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease

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Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of [alpha]-synuclein, and apoptotic cell death in aged mice

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Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of Î±-synuclein, and apoptotic cell death in aged mice

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Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease

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Study on the Putative Contribution of Caspases and the Proteasome to the Degradation of Aph-1a and Pen-2

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