Hollow core of Alzheimer's Aβ₄₂ amyloid observed by cryoEM is relevant at physiological pH
Hollow core of Alzheimer's Aβ₄₂ amyloid observed by cryoEM is relevant at physiological pH
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National Academy of Sciences
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English
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National Academy of Sciences
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Recent cryoEM density maps of Aβ₄₂ fibrils obtained at low pH revealed two protofilaments winding around a hollow core raising the question if such tubular structures also exist at physiological pH. Based on the cryoEM measurements and on NMR data, we probe amyloid fibril organizations corresponding to the observed cryoEM density map. Our study dem...
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Hollow core of Alzheimer's Aβ₄₂ amyloid observed by cryoEM is relevant at physiological pH
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TN_cdi_fao_agris_US201301877683
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_fao_agris_US201301877683
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1004704107
