Analysis of sirtuin 1 expression reveals a molecular explanation of IL-2–mediated reversal of T-cell...
Analysis of sirtuin 1 expression reveals a molecular explanation of IL-2–mediated reversal of T-cell tolerance
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United States: National Academy of Sciences
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English
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United States: National Academy of Sciences
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The type III histone deacetylase sirtuin 1 (Sirt1) is a suppressor of both innate and adoptive immune responses. We have recently found that Sirt1 expression is highly induced in anergic T cells. However, the transcriptional program to regulate Sirt1 expression in T cells remains uncharacterized. Here we report that the early responsive genes 2 and...
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Analysis of sirtuin 1 expression reveals a molecular explanation of IL-2–mediated reversal of T-cell tolerance
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TN_cdi_fao_agris_US201400190358
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_fao_agris_US201400190358
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1118462109
