Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphati...
Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues
About this item
Full title
Author / Creator
Fletcher, Courtney V. , Staskus, Kathryn , Wietgrefe, Stephen W. , Rothenberger, Meghan , Reilly, Cavan , Chipman, Jeffrey G. , Beilman, Greg J. , Khoruts, Alexander , Thorkelson, Ann , Schmidt, Thomas E. , Anderson, Jodi , Perkey, Katherine , Stevenson, Mario , Perelson, Alan S. , Douek, Daniel C. , Haase, Ashley T. and Schacker, Timothy W.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Antiretroviral therapy can reduce HIV-1 to undetectable levels in peripheral blood, but the effectiveness of treatment in suppressing replication in lymphoid tissue reservoirs has not been determined. Here we show in lymph node samples obtained before and during 6 mo of treatment that the tissue concentrations of five of the most frequently used an...
Alternative Titles
Full title
Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues
Authors, Artists and Contributors
Author / Creator
Staskus, Kathryn
Wietgrefe, Stephen W.
Rothenberger, Meghan
Reilly, Cavan
Chipman, Jeffrey G.
Beilman, Greg J.
Khoruts, Alexander
Thorkelson, Ann
Schmidt, Thomas E.
Anderson, Jodi
Perkey, Katherine
Stevenson, Mario
Perelson, Alan S.
Douek, Daniel C.
Haase, Ashley T.
Schacker, Timothy W.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_fao_agris_US201600140407
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_fao_agris_US201600140407
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1318249111
