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ArticlesPeer ReviewedFull Text
Persistent HIV-1 replication maintains the tissue reservoir during therapy
Author / Creator:Lorenzo-Redondo, Ramon ; Fryer, Helen R. ; Bedford, Trevor ; Kim, Eun-Young ; Archer, John ; Kosakovsky Pond, Sergei L. ; Chung, Yoon-Seok ; Penugonda, Sudhir ; Chipman, Jeffrey G. ; Fletcher, Courtney V. ; Schacker, Timothy W. ; Malim, Michael H. ; Rambaut, Andrew ; Haase, Ashley T. ; McLean, Angela R. ; Wolinsky, Steven M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2016-02, Vol.530 (7588), p.51-56
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Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues
Author / Creator:Fletcher, Courtney V. ; Staskus, Kathryn ; Wietgrefe, Stephen W. ; Rothenberger, Meghan ; Reilly, Cavan ; Chipman, Jeffrey G. ; Beilman, Greg J. ; Khoruts, Alexander ; Thorkelson, Ann ; Schmidt, Thomas E. ; Anderson, Jodi ; Perkey, Katherine ; Stevenson, Mario ; Perelson, Alan S. ; Douek, Daniel C. ; Haase, Ashley T. ; Schacker, Timothy W.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2014-02, Vol.111 (6), p.2307-2312
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Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption
Author / Creator:Rothenberger, Meghan K. ; Keele, Brandon F. ; Wietgrefe, Stephen W. ; Fletcher, Courtney V. ; Beilman, Gregory J. ; Chipman, Jeffrey G. ; Khoruts, Alexander ; Estes, Jacob D. ; Anderson, Jodi ; Callisto, Samuel P. ; Schmidt, Thomas E. ; Thorkelson, Ann ; Reilly, Cavan ; Perkey, Katherine ; Reimann, Thomas G. ; Utay, Netanya S. ; Makamdop, Krystelle Nganou ; Stevenson, Mario ; Douek, Daniel C. ; Haase, Ashley T. ; Schacker, Timothy W.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2015-03, Vol.112 (10), p.E1126-E1134
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A novel wastewater-based epidemiology indexing method predicts SARS-CoV-2 disease prevalence across treatment facilities in metropolitan and regional populations
Author / Creator:Melvin, Richard G. ; Hendrickson, Emily N. ; Chaudhry, Nabiha ; Georgewill, Onimitein ; Freese, Rebecca ; Schacker, Timothy W. ; Simmons, Glenn E.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2021-11, Vol.11 (1), p.21368-9, Article 21368
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Microbial translocation is a cause of systemic immune activation in chronic HIV infection
Author / Creator:Brenchley, Jason M ; Price, David A ; Schacker, Timothy W ; Asher, Tedi E ; Silvestri, Guido ; Rao, Srinivas ; Kazzaz, Zachary ; Bornstein, Ethan ; Lambotte, Olivier ; Altmann, Daniel ; Blazar, Bruce R ; Rodriguez, Benigno ; Teixeira-Johnson, Leia ; Landay, Alan ; Martin, Jeffrey N ; Hecht, Frederick M ; Picker, Louis J ; Lederman, Michael M ; Deeks, Steven G ; Douek, Daniel C
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2006-12, Vol.12 (12), p.1365-1371
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ArticlesPeer ReviewedFull Text
Lymphoid Tissue Damage in HIV-1 Infection Depletes Naïve T Cells and Limits T Cell Reconstitution after Antiretroviral Therapy
Author / Creator:Zeng, Ming ; Southern, Peter J. ; Reilly, Cavan S. ; Beilman, Greg J. ; Chipman, Jeffrey G. ; Schacker, Timothy W. ; Haase, Ashley T.
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2012-01, Vol.8 (1), p.e1002437
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ArticlesPeer ReviewedFull Text
Extensive virologic and immunologic characterization in an HIV-infected individual following allogeneic stem cell transplant and analytic cessation of antiretroviral therapy: A case study
Author / Creator:Cummins, Nathan W. ; Rizza, Stacey ; Litzow, Mark R. ; Hua, Stephane ; Lee, Guinevere Q. ; Einkauf, Kevin ; Chun, Tae-Wook ; Rhame, Frank ; Baker, Jason V. ; Busch, Michael P. ; Chomont, Nicolas ; Dean, Patrick G. ; Fromentin, Rémi ; Haase, Ashley T. ; Hampton, Dylan ; Keating, Sheila M. ; Lada, Steven M. ; Lee, Tzong-Hae ; Natesampillai, Sekar ; Richman, Douglas D. ; Schacker, Timothy W. ; Wietgrefe, Stephen ; Yu, Xu G. ; Yao, Joseph D. ; Zeuli, John ; Lichterfeld, Mathias ; Badley, Andrew D.
Publisher:United States: Public Library of Science
Journal title:PLoS medicine, 2017-11, Vol.14 (11), p.e1002461
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ArticlesPeer ReviewedFull Text
Mathematical Modeling Predicts that Increased HSV-2 Shedding in HIV-1 Infected Persons Is Due to Poor Immunologic Control in Ganglia and Genital Mucosa
Author / Creator:Schiffer, Joshua T. ; Swan, David A. ; Magaret, Amalia ; Schacker, Timothy W. ; Wald, Anna ; Corey, Lawrence
Publisher:United States: Public Library of Science
Journal title:PloS one, 2016-06, Vol.11 (6), p.e0155124-e0155124
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ArticlesPeer ReviewedFull Text
Collagen Deposition Limits Immune Reconstitution in the Gut
Author / Creator:Estes, Jacob ; Baker, Jason V. ; Brenchley, Jason M. ; Khoruts, Alex ; Barthold, Jacob L. ; Bantle, Anne ; Reilly, Cavan S. ; Beilman, Gregory J. ; George, Mark E. ; Douek, Daniel C. ; Haase, Ashley T. ; Schacker, Timothy W.
Publisher:United States: The University of Chicago Press
Journal title:The Journal of infectious diseases, 2008-08, Vol.198 (4), p.456-464
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ArticlesPeer ReviewedFull Text
Abnormal Presence of Semimature Dendritic Cells That Induce Regulatory T Cells in HIV-Infected Subjects
Author / Creator:Krathwohl, Mitchell D. ; Schacker, Timothy W. ; Anderson, Jodi L.
Publisher:Chicago, IL: The University of Chicago Press
Journal title:The Journal of infectious diseases, 2006-02, Vol.193 (4), p.494-504
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ArticlesPeer ReviewedFull Text
Positive selection optimizes the number and function of MHCII-restricted CD4⁺ T cell clones in the naive polyclonal repertoire
Author / Creator:Chu, H. Hamlet ; Moon, James J ; Takada, Kensuke ; Pepper, Marion ; Molitor, Jerry A ; Schacker, Timothy W ; Hogquist, Kristin A ; Jameson, Stephen C ; Jenkins, Marc K
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2009-07, Vol.106 (27), p.11241-11245
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ArticlesPeer ReviewedFull Text
Defining total-body AIDS-virus burden with implications for curative strategies
Author / Creator:Estes, Jacob D ; Kityo, Cissy ; Ssali, Francis ; Swainson, Louise ; Makamdop, Krystelle Nganou ; Del Prete, Gregory Q ; Deeks, Steven G ; Luciw, Paul A ; Chipman, Jeffrey G ; Beilman, Gregory J ; Hoskuldsson, Torfi ; Khoruts, Alexander ; Anderson, Jodi ; Deleage, Claire ; Jasurda, Jacob ; Schmidt, Thomas E ; Hafertepe, Michael ; Callisto, Samuel P ; Pearson, Hope ; Reimann, Thomas ; Schuster, Jared ; Schoephoerster, Jordan ; Southern, Peter ; Perkey, Katherine ; Shang, Liang ; Wietgrefe, Stephen W ; Fletcher, Courtney V ; Lifson, Jeffrey D ; Douek, Daniel C ; McCune, Joseph M ; Haase, Ashley T ; Schacker, Timothy W
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2017-11, Vol.23 (11), p.1271-1276
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ArticlesPeer ReviewedFull Text
CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles
Author / Creator:Leong, Yew Ann ; Chen, Yaping ; Ong, Hong Sheng ; Wu, Di ; Man, Kevin ; Deleage, Claire ; Minnich, Martina ; Meckiff, Benjamin J ; Wei, Yunbo ; Hou, Zhaohua ; Zotos, Dimitra ; Fenix, Kevin A ; Atnerkar, Anurag ; Preston, Simon ; Chipman, Jeffrey G ; Beilman, Greg J ; Allison, Cody C ; Sun, Lei ; Wang, Peng ; Xu, Jiawei ; Toe, Jesse G ; Lu, Hao K ; Tao, Yong ; Palendira, Umaimainthan ; Dent, Alexander L ; Landay, Alan L ; Pellegrini, Marc ; Comerford, Iain ; McColl, Shaun R ; Schacker, Timothy W ; Long, Heather M ; Estes, Jacob D ; Busslinger, Meinrad ; Belz, Gabrielle T ; Lewin, Sharon R ; Kallies, Axel ; Yu, Di
Publisher:New York: Nature Publishing Group US
Journal title:Nature immunology, 2016-10, Vol.17 (10), p.1187-1196
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Safety and virologic impact of the IL-15 superagonist N-803 in people living with HIV: a phase 1 trial
Author / Creator:Miller, Jeffrey S. ; Davis, Zachary B. ; Helgeson, Erika ; Reilly, Cavan ; Thorkelson, Ann ; Anderson, Jodi ; Lima, Noemia S. ; Jorstad, Siri ; Hart, Geoffrey T. ; Lee, John H. ; Safrit, Jeffrey T. ; Wong, Hing ; Cooley, Sarah ; Gharu, Lavina ; Chung, Hyunsoo ; Soon-Shiong, Patrick ; Dobrowolski, Curtis ; Fletcher, Courtney V. ; Karn, Jonathan ; Douek, Daniel C. ; Schacker, Timothy W.
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2022-02, Vol.28 (2), p.392-400
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HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation
Author / Creator:Chomont, Nicolas ; El-Far, Mohamed ; Ancuta, Petronela ; Trautmann, Lydie ; Procopio, Francesco A ; Yassine-Diab, Bader ; Boucher, Geneviève ; Boulassel, Mohamed-Rachid ; Ghattas, Georges ; Brenchley, Jason M ; Schacker, Timothy W ; Hill, Brenna J ; Douek, Daniel C ; Routy, Jean-Pierre ; Haddad, Elias K ; Sékaly, Rafick-Pierre
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2009-08, Vol.15 (8), p.893-900
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Evaluation of the Pathogenesis of Decreasing CD4+ T Cell Counts in Human Immunodeficiency Virus Type 1–Infected Patients Receiving Successfully Suppressive Antiretroviral Therapy
Author / Creator:Nies-Kraske, Elizabeth ; Schacker, Timothy W. ; Condoluci, David ; Orenstein, Jan ; Brenchley, Jason ; Fox, Cecil ; Daucher, Marybeth ; Dewar, Robin ; Urban, Elizabeth ; Hill, Brenna ; Guenaga, Javier ; Hoover, Shelley ; Maldarelli, Frank ; Hallahan, Claire W. ; Horn, Judith ; Kottilil, Shyamasundaran ; Chun, Tae-Wook ; Folino, Marlene ; Palmer, Sara ; Wiegand, Ann ; O’Shea, M. Angeline ; Metcalf, Julia A. ; Douek, Daniel C. ; Coffin, John ; Haase, Ashley ; Fauci, Anthony S. ; Dybul, Mark
Publisher:Oxford: The University of Chicago Press
Journal title:The Journal of infectious diseases, 2009-06, Vol.199 (11), p.1648-1656
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Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections
Author / Creator:Zeng, Ming ; Smith, Anthony J ; Wietgrefe, Stephen W ; Southern, Peter J ; Schacker, Timothy W ; Reilly, Cavan S ; Estes, Jacob D ; Burton, Gregory F ; Silvestri, Guido ; Lifson, Jeffrey D ; Carlis, John V ; Haase, Ashley T
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2011-03, Vol.121 (3), p.998-1008
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ArticlesPeer ReviewedFull Text
Valacyclovir for the Suppression of Recurrent Genital Herpes in Human Immunodeficiency Virus–Infected Subjects
Author / Creator:DeJesus, Edwin ; Wald, Anna ; Warren, Terri ; Schacker, Timothy W. ; Trottier, Sylvie ; Shahmanesh, Mohsen ; Hill, Joanne L.
Publisher:Chicago, IL: The University of Chicago Press
Journal title:The Journal of infectious diseases, 2003-10, Vol.188 (7), p.1009-1016
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IL-15 promotes activation and expansion of CD8+ T cells in HIV-1 infection
Author / Creator:Younes, Souheil-Antoine ; Freeman, Michael L. ; Mudd, Joseph C. ; Shive, Carey L. ; Reynaldi, Arnold ; Panigrahi, Soumya ; Estes, Jacob D. ; Deleage, Claire ; Lucero, Carissa ; Anderson, Jodi ; Schacker, Timothy W. ; Davenport, Miles P. ; McCune, Joseph M. ; Hunt, Peter W. ; Lee, Sulggi A. ; Serrano-Villar, Sergio ; Debernardo, Robert L. ; Jacobson, Jeffrey M. ; Canaday, David H. ; Sekaly, Rafick-Pierre ; Rodriguez, Benigno ; Sieg, Scott F. ; Lederman, Michael M.
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2016-07, Vol.126 (7), p.2745-2756
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Conflicting evidence for HIV enrichment in CD32+ CD4 T cells
Author / Creator:Pérez, Liliana ; Anderson, Jodi ; Chipman, Jeffrey ; Thorkelson, Ann ; Chun, Tae-Wook ; Moir, Susan ; Haase, Ashley T. ; Douek, Daniel C. ; Schacker, Timothy W. ; Boritz, Eli A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2018-09, Vol.561 (7723), p.E9-E16
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Showing 1 to 20 of 58 results

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Persistent HIV-1 replication maintains the tissue reservoir during therapy

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Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues

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Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption

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A novel wastewater-based epidemiology indexing method predicts SARS-CoV-2 disease prevalence across treatment facilities in metropolitan and regional populations

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Microbial translocation is a cause of systemic immune activation in chronic HIV infection

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Lymphoid Tissue Damage in HIV-1 Infection Depletes Naïve T Cells and Limits T Cell Reconstitution after Antiretroviral Therapy

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Extensive virologic and immunologic characterization in an HIV-infected individual following allogeneic stem cell transplant and analytic cessation of antiretroviral therapy: A case study

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Mathematical Modeling Predicts that Increased HSV-2 Shedding in HIV-1 Infected Persons Is Due to Poor Immunologic Control in Ganglia and Genital Mucosa

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Collagen Deposition Limits Immune Reconstitution in the Gut

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Abnormal Presence of Semimature Dendritic Cells That Induce Regulatory T Cells in HIV-Infected Subjects

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Positive selection optimizes the number and function of MHCII-restricted CD4⁺ T cell clones in the naive polyclonal repertoire

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Defining total-body AIDS-virus burden with implications for curative strategies

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CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles

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Safety and virologic impact of the IL-15 superagonist N-803 in people living with HIV: a phase 1 trial

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HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

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Evaluation of the Pathogenesis of Decreasing CD4+ T Cell Counts in Human Immunodeficiency Virus Type 1–Infected Patients Receiving Successfully Suppressive Antiretroviral Therapy

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Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections

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Valacyclovir for the Suppression of Recurrent Genital Herpes in Human Immunodeficiency Virus–Infected Subjects

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IL-15 promotes activation and expansion of CD8+ T cells in HIV-1 infection

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Conflicting evidence for HIV enrichment in CD32+ CD4 T cells

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