Allosteric regulation of SERCA by phosphorylation-mediated conformational shift of phospholamban
Allosteric regulation of SERCA by phosphorylation-mediated conformational shift of phospholamban
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
The membrane protein complex between the sarcoplasmic reticulum Ca ²⁺-ATPase (SERCA) and phospholamban (PLN) controls Ca ²⁺ transport in cardiomyocytes, thereby modulating cardiac contractility. β-Adrenergic-stimulated phosphorylation of PLN at Ser-16 enhances SERCA activity via an unknown mechanism. Using solid-state nuclear magnetic resonance spe...
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Full title
Allosteric regulation of SERCA by phosphorylation-mediated conformational shift of phospholamban
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TN_cdi_fao_agris_US201600141670
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_fao_agris_US201600141670
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1303006110
