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Single-molecule superresolution imaging allows quantitative analysis of RAF multimer formation and s...

Single-molecule superresolution imaging allows quantitative analysis of RAF multimer formation and s...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_fao_agris_US201600142010

Single-molecule superresolution imaging allows quantitative analysis of RAF multimer formation and signaling

About this item

Full title

Single-molecule superresolution imaging allows quantitative analysis of RAF multimer formation and signaling

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2013-11, Vol.110 (46), p.18519-18524

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

The RAF serine/threonine kinases regulate cell growth through the MAPK pathway, and are targeted by small-molecule RAF inhibitors (RAFis) in human cancer. It is now apparent that protein multimers play an important role in RAF activation and tumor response to RAFis. However, the exact stoichiometry and cellular location of these multimers remain un...

Alternative Titles

Full title

Single-molecule superresolution imaging allows quantitative analysis of RAF multimer formation and signaling

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_fao_agris_US201600142010

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_fao_agris_US201600142010

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1318188110

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