Single-molecule superresolution imaging allows quantitative analysis of RAF multimer formation and s...
Single-molecule superresolution imaging allows quantitative analysis of RAF multimer formation and signaling
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
The RAF serine/threonine kinases regulate cell growth through the MAPK pathway, and are targeted by small-molecule RAF inhibitors (RAFis) in human cancer. It is now apparent that protein multimers play an important role in RAF activation and tumor response to RAFis. However, the exact stoichiometry and cellular location of these multimers remain un...
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Full title
Single-molecule superresolution imaging allows quantitative analysis of RAF multimer formation and signaling
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Record Identifier
TN_cdi_fao_agris_US201600142010
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_fao_agris_US201600142010
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1318188110
