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Ghrelin receptor conformational dynamics regulate the transition from a preassembled to an active re...

Ghrelin receptor conformational dynamics regulate the transition from a preassembled to an active re...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_fao_agris_US201600145774

Ghrelin receptor conformational dynamics regulate the transition from a preassembled to an active receptor:Gq complex

About this item

Full title

Ghrelin receptor conformational dynamics regulate the transition from a preassembled to an active receptor:Gq complex

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2015-02, Vol.112 (5), p.1601-1606

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Significance G protein-coupled receptors (GPCRs), one of the largest cell surface receptor families, transmit their signals through the coupling of intracellular partners, such as the G proteins. Knowing how this coupling occurs is essential, because it governs the entire signaling process. To address this open question, we used a purified GPCR as...

Alternative Titles

Full title

Ghrelin receptor conformational dynamics regulate the transition from a preassembled to an active receptor:Gq complex

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_fao_agris_US201600145774

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_fao_agris_US201600145774

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1414618112

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