Development of immunoglobulin λ-chain–positive B cells, but not editing of immunoglobulin κ-chain, d...
Development of immunoglobulin λ-chain–positive B cells, but not editing of immunoglobulin κ-chain, depends on NF-κB signals
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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How transcription factor NF-κB influences B cell development remains enigmatic. Rajewsky and colleagues show that NF-κB activation driven by the kinase IKK is required for the generation of B cells expressing immunoglobulin-λ but not immunoglobulin-κ light chains.
By genetically ablating IκB kinase (IKK)-mediated activation of the transcription...
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Full title
Development of immunoglobulin λ-chain–positive B cells, but not editing of immunoglobulin κ-chain, depends on NF-κB signals
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TN_cdi_gale_infotracacademiconefile_A201086702
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracacademiconefile_A201086702
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ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/ni.1732
