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The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node...

The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracacademiconefile_A396527737

The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture

About this item

Full title

The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture

Publisher

Nature Publishing Group

Journal title

Nature immunology, 2015-01, p.75

Language

English

Formats

Publication information

Publisher

Nature Publishing Group

More information

Scope and Contents

Contents

In lymph nodes, fibroblastic reticular cells (FRCs) form a collagen-based reticular network that supports migratory dendritic cells (DCs) and T cells and transports lymph. A hallmark of FRCs is their propensity to contract collagen, yet this function is poorly understood. Here we demonstrate that podoplanin (PDPN) regulates actomyosin contractility...

Alternative Titles

Full title

The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_gale_infotracacademiconefile_A396527737

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracacademiconefile_A396527737

Other Identifiers

ISSN

1529-2908

DOI

10.1038/ni.3035.

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