The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node...
The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture
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Author / Creator
Astarita, Jillian L , Cremasco, Viviana , Fu, Jianxin , Darnell, Max C , Peck, James R , Nieves-Bonilla, Janice M , Song, Kai , Kondo, Yuji , Woodruff, Matthew C , Gogineni, Alvin , Onder, Lucas , Ludewig, Burkhard , Weimer, Robby M , Carroll, Michael C , Mooney, David J , Xia, Lijun and Turley, Shannon J
Publisher
Nature Publishing Group
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English
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Nature Publishing Group
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Contents
In lymph nodes, fibroblastic reticular cells (FRCs) form a collagen-based reticular network that supports migratory dendritic cells (DCs) and T cells and transports lymph. A hallmark of FRCs is their propensity to contract collagen, yet this function is poorly understood. Here we demonstrate that podoplanin (PDPN) regulates actomyosin contractility...
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Full title
The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture
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TN_cdi_gale_infotracacademiconefile_A396527737
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracacademiconefile_A396527737
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ISSN
1529-2908
DOI
10.1038/ni.3035.
