Tumor-secreted Prosi inhibits macrophage M1 polarization to reduce antitumor immune response
Tumor-secreted Prosi inhibits macrophage M1 polarization to reduce antitumor immune response
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American Society for Clinical Investigation
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Language
English
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American Society for Clinical Investigation
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Contents
Tyro3, Axl, Mer (TAM) receptor tyrosine kinases reduce inflammatory, innate immune responses. We demonstrate that tumor-secreted protein S (Pros1), a Mer/Tyro3 ligand, decreased macrophage M1 cytokine expression in vitro and in vivo. In contrast, tumor cells with CRISPR-based deletion of Pros1 failed to inhibit M1 polarization. Tumor cell-associate...
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Full title
Tumor-secreted Prosi inhibits macrophage M1 polarization to reduce antitumor immune response
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TN_cdi_gale_infotracacademiconefile_A543610697
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracacademiconefile_A543610697
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ISSN
0021-9738
DOI
10.1172/JCI97354
