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Tumor-secreted Prosi inhibits macrophage M1 polarization to reduce antitumor immune response

Tumor-secreted Prosi inhibits macrophage M1 polarization to reduce antitumor immune response

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracacademiconefile_A543610697

Tumor-secreted Prosi inhibits macrophage M1 polarization to reduce antitumor immune response

About this item

Full title

Tumor-secreted Prosi inhibits macrophage M1 polarization to reduce antitumor immune response

Publisher

American Society for Clinical Investigation

Journal title

The Journal of clinical investigation, 2018-06, Vol.128 (6), p.2356

Language

English

Formats

Publication information

Publisher

American Society for Clinical Investigation

More information

Scope and Contents

Contents

Tyro3, Axl, Mer (TAM) receptor tyrosine kinases reduce inflammatory, innate immune responses. We demonstrate that tumor-secreted protein S (Pros1), a Mer/Tyro3 ligand, decreased macrophage M1 cytokine expression in vitro and in vivo. In contrast, tumor cells with CRISPR-based deletion of Pros1 failed to inhibit M1 polarization. Tumor cell-associate...

Alternative Titles

Full title

Tumor-secreted Prosi inhibits macrophage M1 polarization to reduce antitumor immune response

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_gale_infotracacademiconefile_A543610697

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracacademiconefile_A543610697

Other Identifiers

ISSN

0021-9738

DOI

10.1172/JCI97354

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