PPAR[gamma] deacetylation dissociates thiazolidinedione's metabolic benefits from its adverse effect...
PPAR[gamma] deacetylation dissociates thiazolidinedione's metabolic benefits from its adverse effects
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Publisher
American Society for Clinical Investigation
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Language
English
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American Society for Clinical Investigation
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Contents
Thiazolidinediones (TZDs) are PPAR[gamma] agonists with potent insulin-sensitizing effects. However, their use has been curtailed by substantial adverse effects on weight, bone, heart, and hemodynamic balance. TZDs induce the deacetylation of PPAR[gamma] on K268 and K293 to cause the browning of white adipocytes. Here, we show that targeted PPAR[ga...
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Full title
PPAR[gamma] deacetylation dissociates thiazolidinedione's metabolic benefits from its adverse effects
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TN_cdi_gale_infotracacademiconefile_A543610714
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracacademiconefile_A543610714
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ISSN
0021-9738
DOI
10.1172/JCI98709
