Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration...
Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-[beta] pathology
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Author / Creator
Suárez-Calvet, Marc , Morenas-Rodríguez, Estrella , Kleinberger, Gernot , Schlepckow, Kai , Caballero, Miguel Ãngel Araque , Franzmeier, Nicolai , Capell, Anja , Fellerer, Katrin , Nuscher, Brigitte , Eren, Erden , Levin, Johannes , Deming, Yuetiva , Piccio, Laura , Karch, Celeste M , Cruchaga, Carlos , Shaw, Leslie M , Trojanowski, John Q , Weiner, Michael , Ewers, Michael , Haass, Christian and ,
Publisher
BioMed Central Ltd
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Language
English
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Publisher
BioMed Central Ltd
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Contents
Background TREM2 is a transmembrane receptor that is predominantly expressed by microglia in the central nervous system. Rare variants in the TREM2 gene increase the risk for late-onset Alzheimer's disease (AD). Soluble TREM2 (sTREM2) resulting from shedding of the TREM2 ectodomain can be detected in the cerebrospinal fluid (CSF) and is a surrogate...
Alternative Titles
Full title
Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-[beta] pathology
Authors, Artists and Contributors
Author / Creator
Morenas-Rodríguez, Estrella
Kleinberger, Gernot
Schlepckow, Kai
Caballero, Miguel Ãngel Araque
Franzmeier, Nicolai
Capell, Anja
Fellerer, Katrin
Nuscher, Brigitte
Eren, Erden
Levin, Johannes
Deming, Yuetiva
Piccio, Laura
Karch, Celeste M
Cruchaga, Carlos
Shaw, Leslie M
Trojanowski, John Q
Weiner, Michael
Ewers, Michael
Haass, Christian
,
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Primary Identifiers
Record Identifier
TN_cdi_gale_infotracacademiconefile_A581404181
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracacademiconefile_A581404181
Other Identifiers
ISSN
1750-1326
E-ISSN
1750-1326
DOI
10.1186/s13024-018-0301-5
