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MEK inhibition reprograms CD8.sup.+ T lymphocytes into memory stem cells with potent antitumor effec...

MEK inhibition reprograms CD8.sup.+ T lymphocytes into memory stem cells with potent antitumor effec...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracacademiconefile_A649637120

MEK inhibition reprograms CD8.sup.+ T lymphocytes into memory stem cells with potent antitumor effects

About this item

Full title

MEK inhibition reprograms CD8.sup.+ T lymphocytes into memory stem cells with potent antitumor effects

Publisher

Nature Publishing Group

Journal title

Nature immunology, 2021-01, Vol.22 (1), p.53

Language

English

Formats

Publication information

Publisher

Nature Publishing Group

More information

Scope and Contents

Contents

Regenerative stem cell-like memory (T.sub.SCM) CD8.sup.+ T cells persist longer and produce stronger effector functions. We found that MEK1/2 inhibition (MEKi) induces T.sub.SCM that have naive phenotype with self-renewability, enhanced multipotency and proliferative capacity. This is achieved by delaying cell division and enhancing mitochondrial b...

Alternative Titles

Full title

MEK inhibition reprograms CD8.sup.+ T lymphocytes into memory stem cells with potent antitumor effects

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_gale_infotracacademiconefile_A649637120

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracacademiconefile_A649637120

Other Identifiers

ISSN

1529-2908

DOI

10.1038/s41590-020-00818-9

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