SMA.sup.+ fibroblasts suppress Lgr5.sup.+ cancer stem cells and restrain colorectal cancer progressi...
SMA.sup.+ fibroblasts suppress Lgr5.sup.+ cancer stem cells and restrain colorectal cancer progression
About this item
Full title
Author / Creator
Publisher
Nature Publishing Group
Journal title
Language
English
Formats
Publication information
Publisher
Nature Publishing Group
Subjects
More information
Scope and Contents
Contents
The development and progression of solid tumors is dependent on cancer cell autonomous drivers and the tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) in the TME possess both tumor-promoting and tumor-restraining functions. In the current study, we interrogated the role of [alpha]SMA.sup.+ CAFs in a genetic mouse model of metasta...
Alternative Titles
Full title
SMA.sup.+ fibroblasts suppress Lgr5.sup.+ cancer stem cells and restrain colorectal cancer progression
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_gale_infotracacademiconefile_A667093019
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracacademiconefile_A667093019
Other Identifiers
ISSN
0950-9232
DOI
10.1038/s41388-021-01866-7
