Secretase modulator resistance of an aggressive Alzheimer-causing presenilin mutant can be overcome...
Secretase modulator resistance of an aggressive Alzheimer-causing presenilin mutant can be overcome in the heterozygous patient state by a set of advanced compounds
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BioMed Central Ltd
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English
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BioMed Central Ltd
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Background Amyloid-[beta] peptide (A[beta]) species of 42 or 43 amino acids in length (A[beta]42/43) trigger Alzheimer´s disease (AD) and are produced in abnormal amounts by mutants of the [gamma]-secretase subunit presenilin-1 (PS1), which represent the primary cause of familial AD (FAD). Lowering these peptides by [gamma]-secretase modulators (GS...
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Secretase modulator resistance of an aggressive Alzheimer-causing presenilin mutant can be overcome in the heterozygous patient state by a set of advanced compounds
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TN_cdi_gale_infotracacademiconefile_A828144957
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracacademiconefile_A828144957
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ISSN
1758-9193
E-ISSN
1758-9193
DOI
10.1186/s13195-025-01680-3
