Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in [CB.sub.1] Receptor Kno...
Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in [CB.sub.1] Receptor Knockout Mice
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American Association for the Advancement of Science
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English
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American Association for the Advancement of Science
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The function of the central cannabinoid receptor ([CB.sub.1]) was investigated by invalidating its gene. Mutant mice did not respond to cannabinoid drugs, demonstrating the exclusive rote of the [CB.sub.1] receptor in mediating analgesia, reinforcement, hypothermia, hypolocomotion, and hypotension. The acute effects of opiates were unaffected, but...
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Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in [CB.sub.1] Receptor Knockout Mice
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TN_cdi_gale_infotracgeneralonefile_A54396875
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracgeneralonefile_A54396875
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ISSN
0036-8075
