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Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms

Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracgeneralonefile_A639815497

Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms

About this item

Full title

Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms

Publisher

Nature Publishing Group

Journal title

Nature, 2020, Vol.586 (7831), p.807

Language

English

Formats

Publication information

Publisher

Nature Publishing Group

More information

Scope and Contents

Contents

The serum level of iron in humans is tightly controlled by the action of the hormone hepcidin on the iron efflux transporter ferroportin. Hepcidin regulates iron absorption and recycling by inducing the internalization and degradation of ferroportin.sup.1. Aberrant ferroportin activity can lead to diseases of iron overload, such as haemochromatosis...

Alternative Titles

Full title

Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_gale_infotracgeneralonefile_A639815497

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracgeneralonefile_A639815497

Other Identifiers

ISSN

0028-0836

DOI

10.1038/s41586-020-2668-z

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