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Cholinergic dysfunction in the dorsal striatum promotes habit formation and maladaptive eating

Cholinergic dysfunction in the dorsal striatum promotes habit formation and maladaptive eating

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracgeneralonefile_A644418777

Cholinergic dysfunction in the dorsal striatum promotes habit formation and maladaptive eating

About this item

Full title

Cholinergic dysfunction in the dorsal striatum promotes habit formation and maladaptive eating

Publisher

United States: American Society for Clinical Investigation

Journal title

The Journal of clinical investigation, 2020-12, Vol.130 (12), p.6616-6630

Language

English

Formats

Publication information

Publisher

United States: American Society for Clinical Investigation

More information

Scope and Contents

Contents

Dysregulation of habit formation has been recently proposed as pivotal to eating disorders. Here, we report that a subset of patients suffering from restrictive anorexia nervosa have enhanced habit formation compared with healthy controls. Habit formation is modulated by striatal cholinergic interneurons. These interneurons express vesicular transp...

Alternative Titles

Full title

Cholinergic dysfunction in the dorsal striatum promotes habit formation and maladaptive eating

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_gale_infotracgeneralonefile_A644418777

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracgeneralonefile_A644418777

Other Identifiers

ISSN

0021-9738

E-ISSN

1558-8238

DOI

10.1172/JCI138532

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